INT351503

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IKBKAP) nucleolus (IKBKAP) nucleus (IKBKAP)
protein complex assembly (IKBKAP) DNA binding (IKBKAP) cytoplasm (IKBKAP)
Anatomy Link Frequency
peripheral nervous system 2
IKBKAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Peripheral nervous system 2 98.80 Very High Very High Very High
Pain 2 64.96 Quite High
imagery 4 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 242 99.84 Very High Very High Very High
Gastric Motility Disorder 2 74.04 Quite High
Hypertension 2 70.08 Quite High
Pressure Volume 2 Under Development 2 69.04 Quite High
Pain 2 64.96 Quite High
Disease 22 57.84 Quite High
Diabetic Nephropathy 2 50.52 Quite High
Syndrome 2 48.72 Quite Low
Neuropathic Pain 2 40.68 Quite Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This mutation leads to variable, tissue-specific skipping of exon 20 of IKBKAP mRNA, with the central and peripheral nervous system more prone to complete skipping than others tissues, which leads to reduced IKAP/hELP1 protein levels [8].
Positive_regulation (leads) of Negative_regulation (reduced) of IKAP/hELP1 in peripheral nervous system associated with peripheral nervous system
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.61 Pain Relevance 0.11
Moreover, we showed that kinetin improved exon 20 inclusion and restores a normal level of IKAP/hELP1 in FD hOE-MSCs.
Positive_regulation (restores) of Negative_regulation (level) of IKAP/hELP1 associated with familial dysautonomia
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3004942 Disease Relevance 0.88 Pain Relevance 0

General Comments

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