INT351514

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PMEPA1) molecular_function (PMEPA1)
PMEPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 4 28.84 Quite Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 242 98.84 Very High Very High Very High
Apoptosis 4 91.92 High High
Disease 22 62.16 Quite High
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Rare Diseases 4 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Embryonic Lethality 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, 2 genes, PMEPA1 and GSN (encoding TMEPAI and gelsolin, respectively), involved in cell growth and cytoskeleton organization, respectively, were dysregulated in both the IKBKAP RNAi and FD iPS cell studies.
Regulation (dysregulated) of PMEPA1 associated with familial dysautonomia
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.60 Pain Relevance 0
We confirmed that PMEPA1 (Figure 4A), the most dysregulated gene on the microarray, and S100A16 (Figure 4B), were significantly underexpressed in FD samples.
Regulation (dysregulated) of PMEPA1 associated with familial dysautonomia
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.58 Pain Relevance 0

General Comments

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