INT351518

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GNAS) intracellular (GNAS) GTPase activity (GNAS)
transmembrane transport (GNAS) cytoplasm (GNAS) signal transducer activity (GNAS)
GNAS (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 242 99.48 Very High Very High Very High
Neuropathic Pain 2 60.96 Quite High
Disease 22 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Rare Diseases 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Embryonic Lethality 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed a significant lower expression of both IKBKAP transcript and IKAP/hELP1 protein in FD cells resulting from the degradation of the transcript isoform skipping exon 20.
Protein_catabolism (degradation) of exon associated with familial dysautonomia
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3004942 Disease Relevance 0.94 Pain Relevance 0
In addition, we tested for the stability of exon 36-containing transcripts after cycloheximide treatment.
Protein_catabolism (stability) of exon
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.36 Pain Relevance 0

General Comments

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