INT351522

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Context Info
Confidence 0.80
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 5.05
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IKBKAP) nucleolus (IKBKAP) nucleus (IKBKAP)
protein complex assembly (IKBKAP) DNA binding (IKBKAP) cytoplasm (IKBKAP)
Anatomy Link Frequency
nucleus 2
nervous tissues 1
olfactory mucosa 1
IKBKAP (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 20 94.92 High High
Potency 10 85.84 High High
Peripheral nervous system 10 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 1210 100.00 Very High Very High Very High
Rheumatoid Arthritis 10 89.92 High High
Disease 110 73.84 Quite High
Neuropathic Pain 10 58.60 Quite High
Neurodegenerative Disease 10 50.76 Quite High
Neurological Disease 10 26.24 Quite Low
Targeted Disruption 30 5.00 Very Low Very Low Very Low
Rare Diseases 20 5.00 Very Low Very Low Very Low
Apoptosis 20 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As observed in most published studies, we observed that the immunolocalization of IKAP/hELP1 was mainly cytoplasmic within the perinuclear area.
Localization (immunolocalization) of IKAP/hELP1
1) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.25 Pain Relevance 0
We localized IKAP/hELP1 in different cell compartments, including the nucleus, which supports multiple roles for that protein.
Localization (localized) of IKAP/hELP1 in nucleus
2) Confidence 0.80 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3004942 Disease Relevance 0.93 Pain Relevance 0
So far, the proposed functions of IKAP/hELP1 are related to various cellular localizations.
Localization (localizations) of IKAP/hELP1
3) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.30 Pain Relevance 0
Since the localization of IKAP/hELP1 remains controversial and is important to understand protein functions, we stained both control and FD hOE-MSCs with the monoclonal antibody directed against IKAP/hELP1 and previously used for detecting the protein by western blot analysis.
Localization (localization) of IKAP/hELP1 associated with familial dysautonomia
4) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.51 Pain Relevance 0.04
We could also detect the presence of IKAP/hELP1 in the nucleus of hOE-MSCs (Figure 3A–C).
Localization (presence) of IKAP/hELP1 in nucleus
5) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.44 Pain Relevance 0.05
MU IKBKAP isoform ratio in nervous tissues [8], and suggests that stem cells engaged in a neuronal lineage with appropriate culture conditions can rapidly switch their IKBKAP WT?
Localization (ratio) of IKBKAP in nervous tissues
6) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.45 Pain Relevance 0
We observed a significant increase of IKBKAP exon 20 inclusion in spheres, when compared to hOE-MSCs in serum conditions, as well as a semi-disappearance of IKBKAP exon 20 skipping (Figure 8G).
Localization (disappearance) of IKBKAP exon 20
7) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.58 Pain Relevance 0
We observed a significant increase of IKBKAP exon 20 inclusion in spheres, when compared to hOE-MSCs in serum conditions, as well as a semi-disappearance of IKBKAP exon 20 skipping (Figure 8G).
Localization (disappearance) of IKBKAP exon 20
8) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.61 Pain Relevance 0
To establish a human cellular model of FD, we collected 4 olfactory mucosa biopsies from homozygous patients for the IVS20+6T?
Localization (model) of FD in olfactory mucosa associated with familial dysautonomia
9) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.88 Pain Relevance 0.04
The assay IDs were the following: Hs00375306_m1 (PMEPA1) and Hs00293488_m1 (S100A16) for the dysregulated genes in FD, and Hs01003267_m1 (HPRT1) and Hs00293488_m1 (RPLP0) for reference genes used to normalize the data.
Localization (normalize) of FD associated with familial dysautonomia
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.10 Pain Relevance 0

General Comments

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