INT351577

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.77
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (LPAR6) signal transducer activity (LPAR6)
LPAR6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 84.96 Quite High
Pain 2 76.16 Quite High
Inflammatory response 4 67.52 Quite High
antagonist 12 59.36 Quite High
fibrosis 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 100 99.84 Very High Very High Very High
Hepatitis D Virus Infection 110 99.64 Very High Very High Very High
Hepatitis B Virus Infection 86 97.74 Very High Very High Very High
INFLAMMATION 16 84.96 Quite High
Vesicular Stomatitis 4 78.72 Quite High
Pain 2 76.16 Quite High
Toxicity 6 64.84 Quite High
Hepatitis 6 64.56 Quite High
Hepatotoxicity 2 34.24 Quite Low
Fibrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, a speculation is that post-attachment processing of preS1 domains on the surface of HDV and HBV is essential for virus entry, and that this processing can be inhibited by heparin and preS1 peptide as well as inhibition of purinergic receptor functionality.
Negative_regulation (inhibition) of purinergic receptor associated with hepatitis d virus infection and hepatitis b virus infection
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004961 Disease Relevance 0.73 Pain Relevance 0.08
Together, these two control studies support the interpretation that suramin, PPADS and BBG block HDV infection via an inhibition of an essential purinergic receptor function.
Negative_regulation (inhibition) of purinergic receptor associated with hepatitis d virus infection and infection
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004961 Disease Relevance 1.05 Pain Relevance 0.15

General Comments

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