INT351587

Context Info Confidence 0.29 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.81 Pain Relevance 0.92

cell differentiation (Uhrf2) cell proliferation (Uhrf2) histone binding (Uhrf2) nucleus (Uhrf2) cell cycle (Uhrf2) DNA binding (Uhrf2)

Anatomy Link Frequency brain 4 Uhrf2 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 54 100.00 anesthesia 6 97.40 isoflurane 3 87.00 ischemia 12 83.76 Deep tissue 6 5.00 Arthritis 3 5.00

Disease Link Frequency Relevance Heat Cancer 12 96.80 Cv General 4 Under Development 12 84.48 Middle Cerebral Artery Infarction 3 82.16 Stroke 12 76.92 Animal Disease Models 6 5.00 Brain Disease 6 5.00 Arthritis 3 5.00 Increased Venous Pressure Under Development 3 5.00 Neurodegenerative Disease 3 5.00 Brain Tumor 3 5.00

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NIRF imaging was performed 2 h after injection of Cy5.5-albumin and the brain was then removed from the skull under deep anesthesia and used for ex vivo NIRF imaging [Fig. 4

Positive_regulation (-) of Gene_expression (imaging) of NIRF in brain associated with anesthesia and imagery

1) Confidence 0.29 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3005168 Disease Relevance 0.34 Pain Relevance 0.40

NIRF imaging was performed 2 h after injection of Cy5.5-albumin and the brain was then removed from the skull under deep anesthesia and used for ex vivo NIRF imaging [Fig. 4

Positive_regulation (performed) of Gene_expression (imaging) of NIRF in brain associated with anesthesia and imagery

2) Confidence 0.29 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3005168 Disease Relevance 0.34 Pain Relevance 0.40

The dye was allowed to equilibrate for 1 min before NIRF imaging ?

Positive_regulation (equilibrate) of Gene_expression (imaging) of NIRF associated with imagery

3) Confidence 0.29 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3005168 Disease Relevance 0.13 Pain Relevance 0.13

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