INT351676

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Fut1) extracellular matrix organization (Ptk2) cytoplasm (Ptk2)
signal transducer activity (Ptk2) cytosol (Ptk2) nucleolus (Ptk2)
Fut1 (Mus musculus)
Ptk2 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioblastoma 40 99.90 Very High Very High Very High
Malignant Neoplastic Disease 16 99.64 Very High Very High Very High
Glioma 188 98.52 Very High Very High Very High
Cancer 260 95.40 Very High Very High Very High
Adenocarcinoma 4 91.44 High High
Apoptosis 8 86.40 High High
Brain Tumor 8 83.28 Quite High
Adhesions 44 76.72 Quite High
Metastasis 12 72.40 Quite High
Pressure And Volume Under Development 8 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results provide evidence that downregulation of FAK and phosphorylated FAK by hUCBSC resulted in decrease in the expression of VEGF which resulted in the attenuated migration of U251 and 5310 cells, and hence regression of tumor growth in vivo.
hUCBSC Negative_regulation (downregulation) of FAK associated with cancer
1) Confidence 0.01 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.91 Pain Relevance 0
This proves our hypothesis that hUCBSC probably downregulate FAK in order to inhibit angiogenesis of glioma cells.
hUCBSC Negative_regulation (downregulate) of FAK associated with glioma
2) Confidence 0.01 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.71 Pain Relevance 0
Here, we provide evidence suggesting that FAK promotes angiogenesis in malignant glioblastoma and hUCBSC downregulated FAK, thereby inhibiting vessel formation.
hUCBSC Negative_regulation (downregulated) of FAK associated with malignant neoplastic disease and glioblastoma
3) Confidence 0.01 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.86 Pain Relevance 0
Our results provide evidence that downregulation of FAK and phosphorylated FAK by hUCBSC resulted in decrease in the expression of VEGF which resulted in the attenuated migration of U251 and 5310 cells, and hence regression of tumor growth in vivo.
hUCBSC Negative_regulation (downregulation) of FAK associated with cancer
4) Confidence 0.01 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.91 Pain Relevance 0

General Comments

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