INT351677

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 3.64 Pain Relevance 0

transferase activity, transferring glycosyl groups (Fut1) extracellular matrix organization (Ptk2) cytoplasm (Ptk2) signal transducer activity (Ptk2) cytosol (Ptk2) nucleolus (Ptk2)

Fut1 (Mus musculus) Ptk2 (Mus musculus)

Pain Link Frequency Relevance Heat ketamine 3 5.00 anesthesia 3 5.00

Disease Link Frequency Relevance Heat Glioma 141 100.00 Cancer 195 98.28 Glioblastoma 30 96.44 Malignant Neoplastic Disease 12 95.92 Brain Tumor 6 94.40 Apoptosis 6 83.04 Adhesions 33 73.36 Metastasis 9 69.04 Pressure And Volume Under Development 6 63.80 Blastoma 3 39.56

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found an elevated expression of FAK in the glioma cells, which was highly downregulated by hUCBSC in the co-cultures.

hUCBSC Negative_regulation (downregulated) of Gene_expression (expression) of FAK associated with glioma

1) Confidence 0.01 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.89 Pain Relevance 0

Moreover, hUCBSC inhibited the expression of FAK and related angiogenic molecules in the xenografts.

hUCBSC Negative_regulation (inhibited) of Gene_expression (expression) of FAK

2) Confidence 0.01 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 1.13 Pain Relevance 0

We evaluated the expression of FAK by immunofluorescence and observed that hUCBSC inhibited the expression of FAK (Figure 3A).

hUCBSC Negative_regulation (inhibited) of Gene_expression (expression) of FAK

3) Confidence 0.01 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.62 Pain Relevance 0

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