INT351715

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pax3, Adarb1) nucleoplasm (Adarb1) intracellular (Adarb1)
DNA binding (Pax3) cell proliferation (Pax3) RNA binding (Adarb1)
Pax3 (Mus musculus)
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 82 100.00 Very High Very High Very High
nMDA receptor 29 100.00 Very High Very High Very High
antagonist 23 98.92 Very High Very High Very High
Spinal cord 7 91.56 High High
withdrawal 52 87.28 High High
lumbar region 1 87.00 High High
nMDA receptor antagonist 2 64.16 Quite High
agonist 2 41.76 Quite Low
c fibre 22 39.40 Quite Low
qutenza 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 6 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 1 5.00 Very Low Very Low Very Low
Acidosis 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A parsimonious explanation would therefore be that the lack of effect of APV in naked mole-rats is linked to a lack of endogenous SP-mediated sensitization of NMDA receptors.


SP-mediated Negative_regulation (sensitization) of receptors associated with nmda receptor, antagonist and substance p
1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006196 Disease Relevance 0 Pain Relevance 1.19

General Comments

This test has worked.

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