INT35174

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 5.22
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
lymphocytes 4
macrophage 2
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 3 95.36 Very High Very High Very High
cytokine 43 79.20 Quite High
Inflammation 55 77.52 Quite High
fibrosis 20 74.96 Quite High
chemokine 9 67.92 Quite High
cINOD 2 66.24 Quite High
cOX1 3 65.84 Quite High
Inflammatory response 13 61.72 Quite High
alcohol 5 22.92 Low Low
sodium channel 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 4 99.96 Very High Very High Very High
Heart Rate Under Development 14 99.28 Very High Very High Very High
Cv General 3 Under Development 3 95.36 Very High Very High Very High
Cancer 68 94.92 High High
Myocardial Infarction 1 93.84 High High
Fever 2 92.76 High High
Acute-phase Reaction 2 92.20 High High
Cirrhosis 45 90.64 High High
Non-small-cell Lung Cancer 18 90.60 High High
Alcoholic Liver Diseases 19 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation with hr CRP, which was equivalent to the serum concentration in patients with acute coronary syndrome, induced IL-18 release.
Positive_regulation (induced) of Localization (release) of IL-18 associated with acute coronary syndrome
1) Confidence 0.69 Published 2003 Journal Heart Vessels Section Abstract Doc Link 14520485 Disease Relevance 0.88 Pain Relevance 0.27
Increased secretion of IL-18 is induced in patients with CHF and correlates with the severity of myocardial damage and dysfunction.
Positive_regulation (induced) of Localization (secretion) of IL-18 associated with heart rate under development
2) Confidence 0.33 Published 2000 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 11758978 Disease Relevance 0.82 Pain Relevance 0.14
Increased secretion of IL-18 is induced in patients with CHF and correlates with the severity of myocardial damage and dysfunction.
Positive_regulation (Increased) of Localization (secretion) of IL-18 associated with heart rate under development
3) Confidence 0.33 Published 2000 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 11758978 Disease Relevance 0.83 Pain Relevance 0.14
However, they can also do the opposite in alcoholics exposed to high levels of LPS by releasing IL-12 and IL-18, which can recruit natural killer T cells as well as both CD8+ and CD4+ lymphocytes.
Positive_regulation (exposed) of Localization (releasing) of IL-18 in lymphocytes
4) Confidence 0.10 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.34 Pain Relevance 0.19
1, and increasing release of TNF, IL-15 and IL-18.
Positive_regulation (increasing) of Localization (release) of IL-18
5) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.90 Pain Relevance 0.10
Interferon-gamma also synergizes with a variety of microbial agents to augment macrophage tumoricidal function and enhance interleukin-1 secretion.
Positive_regulation (enhance) of Localization (secretion) of interleukin-1 in macrophage
6) Confidence 0.05 Published 1987 Journal Toxicol Pathol Section Abstract Doc Link 3120294 Disease Relevance 0.20 Pain Relevance 0.21
Upon activation, macrophages release interleukin-1 (alias lymphocyte activating factor, leukocytic endogenous mediator, and endogenous pyrogen), a family of molecules with multivarious biological effects, ranging from induction of fever and the acute phase response to lymphocyte activation and concomitant release of interleukin-2.
Positive_regulation (activation) of Localization (release) of interleukin-1 in lymphocyte associated with acute-phase reaction and fever
7) Confidence 0.03 Published 1987 Journal Toxicol Pathol Section Abstract Doc Link 3120294 Disease Relevance 0.24 Pain Relevance 0.04

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