INT35175

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Context Info
Confidence 0.80
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 12.96
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
monocytes 2
lymphocytes 2
mononuclear cells 2
Plasma 1
macrophage 1
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 187 100.00 Very High Very High Very High
cytokine 174 100.00 Very High Very High Very High
Angina 4 95.04 Very High Very High Very High
aspirin 8 90.48 High High
corticosteroid 8 89.72 High High
antagonist 7 88.08 High High
anakinra 1 86.48 High High
cINOD 6 86.40 High High
headache 8 82.52 Quite High
vagus nerve 8 79.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 233 100.00 Very High Very High Very High
Acute Coronary Syndrome 12 99.80 Very High Very High Very High
Heart Rate Under Development 8 98.84 Very High Very High Very High
Disease 259 97.52 Very High Very High Very High
Syndrome 1 96.64 Very High Very High Very High
Crystal Associated Disease 4 96.44 Very High Very High Very High
Cv General 3 Under Development 8 95.04 Very High Very High Very High
Cancer 125 94.48 High High
Myocardial Infarction 14 93.52 High High
Fever 20 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the mechanism of accelerating IL-18 production, we examined the release of IL-18 in human endothelial cells using human recombinant (hr) C-reactive protein (CRP) as a stimulator of IL-18.
Spec (examined) Localization (release) of IL-18 in endothelial cells
1) Confidence 0.80 Published 2003 Journal Heart Vessels Section Abstract Doc Link 14520485 Disease Relevance 0.74 Pain Relevance 0.20
Incubation with hr CRP, which was equivalent to the serum concentration in patients with acute coronary syndrome, induced IL-18 release.
Localization (release) of IL-18 associated with acute coronary syndrome
2) Confidence 0.80 Published 2003 Journal Heart Vessels Section Abstract Doc Link 14520485 Disease Relevance 0.88 Pain Relevance 0.27
Treatment with hr IL-10 inhibited IL-18 release in the cells stimulated with hr CRP.
Localization (release) of IL-18
3) Confidence 0.80 Published 2003 Journal Heart Vessels Section Abstract Doc Link 14520485 Disease Relevance 0.87 Pain Relevance 0.27
IL18 polymorphisms selection
Localization (selection) of IL18
4) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 0.85 Pain Relevance 0.17
In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC.
Localization (secretion) of IL-18 in PBMC
5) Confidence 0.61 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 17072982 Disease Relevance 0 Pain Relevance 0
Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%.
Localization (secretion) of IL-18
6) Confidence 0.61 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 17072982 Disease Relevance 0 Pain Relevance 0
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Localization (release) of IL-18 in monocytes
7) Confidence 0.58 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.23 Pain Relevance 0.37
Increased secretion of IL-18 is induced in patients with CHF and correlates with the severity of myocardial damage and dysfunction.
Localization (secretion) of IL-18 associated with heart rate under development
8) Confidence 0.39 Published 2000 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 11758978 Disease Relevance 0.82 Pain Relevance 0.14
Plasma profiling of SJIA flare and quiescent samples using this antibody array identified a biomarker panel of TIMP1, IL-18, RANTES, P-Selectin, MMP9, and L-Selectin, all of which are present at higher abundance in SJIA flare than in quiescence.
Localization (panel) of IL-18 in Plasma
9) Confidence 0.38 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.72 Pain Relevance 0.22
When DCs or monocytes-macrophages encounter a pathogen and release cytokines such as IL-12, IL-15, IL-18, TNF-?
Localization (release) of IL-18 in monocytes associated with cytokine
10) Confidence 0.20 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.67 Pain Relevance 0.05
IL-18 is a pro-inflammatory cytokine secreted by mononuclear cells.
Localization (secreted) of IL-18 in mononuclear cells associated with inflammation and cytokine
11) Confidence 0.18 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2841501 Disease Relevance 1.12 Pain Relevance 0.22
However, they can also do the opposite in alcoholics exposed to high levels of LPS by releasing IL-12 and IL-18, which can recruit natural killer T cells as well as both CD8+ and CD4+ lymphocytes.
Localization (releasing) of IL-18 in lymphocytes
12) Confidence 0.16 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.33 Pain Relevance 0.19
1, and increasing release of TNF, IL-15 and IL-18.
Localization (release) of IL-18
13) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.90 Pain Relevance 0.10
and IL-18 secretion by activating caspase-1, causes a familial auto inflammatory disease, Muckel Wells syndrome.
Localization (secretion) of IL-18 associated with inflammation, syndrome and disease
14) Confidence 0.12 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.04 Pain Relevance 0.27
Th2 responses are mediated through the secretion of a different set of cytokines, primarily interleukin-1, interleukin-4, interleukin-6, interleukin-10, and interleukin-13, and B cells, eosinophils, and mast cells [11].
Localization (secretion) of interleukin-1 in eosinophils associated with cytokine
15) Confidence 0.11 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 0.78 Pain Relevance 0.37
Upon activation, macrophages release interleukin-1 (alias lymphocyte activating factor, leukocytic endogenous mediator, and endogenous pyrogen), a family of molecules with multivarious biological effects, ranging from induction of fever and the acute phase response to lymphocyte activation and concomitant release of interleukin-2.
Localization (release) of interleukin-1 in lymphocyte associated with acute-phase reaction and fever
16) Confidence 0.05 Published 1987 Journal Toxicol Pathol Section Abstract Doc Link 3120294 Disease Relevance 0.24 Pain Relevance 0.04
Interferon-gamma also synergizes with a variety of microbial agents to augment macrophage tumoricidal function and enhance interleukin-1 secretion.
Localization (secretion) of interleukin-1 in macrophage
17) Confidence 0.05 Published 1987 Journal Toxicol Pathol Section Abstract Doc Link 3120294 Disease Relevance 0.20 Pain Relevance 0.21
Th2 responses are mediated through the secretion of a different set of cytokines, primarily interleukin-1, interleukin-4, interleukin-6, interleukin-10, and interleukin-13, and B cells, eosinophils, and mast cells [11].
Localization (secretion) of interleukin-1 in mast cells associated with cytokine
18) Confidence 0.04 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 0.78 Pain Relevance 0.37
Th2 responses are mediated through the secretion of a different set of cytokines, primarily interleukin-1, interleukin-4, interleukin-6, interleukin-10, and interleukin-13, and B cells, eosinophils, and mast cells [11].
Localization (secretion) of interleukin-1 in B cells associated with cytokine
19) Confidence 0.04 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 0.78 Pain Relevance 0.37

General Comments

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