INT351760

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.70
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) transport (Gria2) endoplasmic reticulum (Gria2)
intracellular (Adarb1) protein complex (Gria2) RNA binding (Adarb1)
Anatomy Link Frequency
neurons 1
Adarb1 (Mus musculus)
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 12 83.60 Quite High
ischemia 8 62.08 Quite High
Spinal cord 2 39.68 Quite Low
adenocard 8 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 99.36 Very High Very High Very High
Thiamine Deficiency 124 99.32 Very High Very High Very High
Death 26 66.32 Quite High
Brain Hemorrhage 2 62.08 Quite High
Motor Neuron Diseases 6 61.32 Quite High
Toxicity 2 48.64 Quite Low
Disease 12 41.36 Quite Low
Neurological Disease 4 41.00 Quite Low
Frailty 2 39.96 Quite Low
Cv Unclassified Under Development 6 38.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further determine the role of ADAR2 in AMPA-mediated Ca2+ influx and TD-induced cytoxicity, we manipulated the expression of ADAR2 in cortical neurons.
ADAR2 Spec (determine) Regulation (role) of AMPA-mediated in neurons associated with thiamine deficiency
1) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.68 Pain Relevance 0
The pre-mRNA editing of GluR2 at the Q/R site is regulated by a nuclear enzyme, ADAR2.
ADAR2 Regulation (regulated) of GluR2
2) Confidence 0.26 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 1.02 Pain Relevance 0.07

General Comments

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