INT351853

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.68
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pdk2) nucleolus (Pdk2) nucleus (Pdk2)
carbohydrate metabolic process (Pdk2) kinase activity (Pdk2) cytoplasm (Pdk2)
Pdk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 5 83.48 Quite High
fibrosis 20 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
Angina 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 40 88.04 High High
Cv Unclassified Under Development 5 83.48 Quite High
Hepatitis Virus Infection 5 78.64 Quite High
Cirrhosis 30 27.76 Quite Low
Increased Venous Pressure Under Development 5 15.00 Low Low
Hepatotoxicity 25 5.00 Very Low Very Low Very Low
Fibrosis 15 5.00 Very Low Very Low Very Low
Death 10 5.00 Very Low Very Low Very Low
Necrosis 10 5.00 Very Low Very Low Very Low
Liver Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-carnitine (prior to CCl4 injection) resulted in a significant increase in isoenzyme 2, isoenzyme 3 and isoenzyme 4; and a significant decrease in isoenzyme 1 and isoenzyme 5.
Positive_regulation (increase) of isoenzyme 2
1) Confidence 0.05 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.17 Pain Relevance 0.04
Treatment with L-carnitine (prior to CCl4 injection) resulted in a significant increase in isoenzyme 2, isoenzyme 3 and isoenzyme 4, a significant decrease in isoenzyme 5, whereas isoenzyme 1 was still absent.
Positive_regulation (increase) of isoenzyme 2
2) Confidence 0.04 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.14 Pain Relevance 0
Treatment with a combination of L-carnitine and coenzyme Q10 (prior to CCl4 injection) resulted in a significant increase in isoenzyme 4 and a significant decrease in isoenzyme 1, isoenzyme 2, isoenzyme 3 and isoenzyme 5.
Positive_regulation (increase) of isoenzyme 2
3) Confidence 0.04 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.22 Pain Relevance 0.04
Treatment with a combination of L-carnitine and coenzyme Q10 (prior to CCl4 injection) resulted in a significant increase in isoenzyme 2, isoenzyme 3 and isoenzyme 4, a significant decrease in isoenzyme 5, whereas isoenzyme 1 was still absent.


Positive_regulation (increase) of isoenzyme 2
4) Confidence 0.04 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.07 Pain Relevance 0
Treatment with coenzyme Q10 (prior to CCl4 injection) resulted in a significant increase in isoenzyme 2, isoenzyme 3 and isoenzyme 4, a significant decrease in isoenzyme 5, whereas isoenzyme 1 was still absent.
Positive_regulation (increase) of isoenzyme 2
5) Confidence 0.04 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.08 Pain Relevance 0

General Comments

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