INT351969

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 23
Disease Relevance 21.03
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Stk11) mitochondrion (Stk11) nucleus (Stk11)
cell cycle (Stk11) protein complex (Stk11) cytoplasm (Stk11)
Anatomy Link Frequency
carotid artery 8
cardiac myocyte 2
smooth muscle cells 2
Stk11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 46 95.92 Very High Very High Very High
ketamine 23 5.00 Very Low Very Low Very Low
anesthesia 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 483 99.98 Very High Very High Very High
Neointima 483 99.84 Very High Very High Very High
Vasculitis 138 99.72 Very High Very High Very High
Cancer 253 99.48 Very High Very High Very High
Necrosis 23 95.20 Very High Very High Very High
Increased Venous Pressure Under Development 46 94.36 High High
Hypertrophy 23 94.34 High High
Cardiovascular Disease 138 93.12 High High
Congenital Anomalies 23 90.52 High High
Embryonic Lethality 23 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, we failed to transfect LKB1 to evaluate the direct effect of LKB1, with or without AII stimulation, on proliferation of VSMC in vitro and in vivo.
Neg (failed) Positive_regulation (transfect) of Neg (failed) Gene_expression (transfect) of LKB1
1) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.32 Pain Relevance 0
Ang II augmented the increased expression of LKB1.
Positive_regulation (increased) of Gene_expression (expression) of LKB1
2) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.19 Pain Relevance 0
Although endogenous Ang II increased after vascular injury, the mechanisms of the interaction between Ang II, increased LKB1 expression and decreased LKB1 kinase activity is still elusive.
Positive_regulation (increased) of Gene_expression (expression) of LKB1 associated with vasculitis
3) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.67 Pain Relevance 0
Serial LKB1 staining showed LKB1 expression increased 5 days after the balloon injury and peaked 14 days after the injury according to neointima formation (Fig. 3).


Positive_regulation (increased) of Gene_expression (expression) of LKB1 associated with injury and neointima
4) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.24 Pain Relevance 0
LKB1 expression increased in neointima of balloon-injured carotid arteries
Positive_regulation (increased) of Gene_expression (expression) of LKB1 associated with neointima
5) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.05 Pain Relevance 0.04
Immunohistochemistry showed increased LKB1 expression after the carotid artery balloon injury compared to the control group (Fig. 2D and E).
Positive_regulation (increased) of Gene_expression (expression) of LKB1 in carotid artery associated with injury
6) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.34 Pain Relevance 0.03
We found increased expression of LKB1 under Ang II stimulated conditions.
Positive_regulation (increased) of Gene_expression (expression) of LKB1
7) Confidence 0.67 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.51 Pain Relevance 0.05
Ang II augmented the increased expression of LKB1 (Fig. 2F).
Positive_regulation (increased) of Gene_expression (expression) of LKB1
8) Confidence 0.49 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.32 Pain Relevance 0.03
Angiotensin II increased LKB1 expression in vascular smooth muscle cells
Positive_regulation (increased) of Gene_expression (expression) of LKB1 in smooth muscle cells
9) Confidence 0.49 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.33 Pain Relevance 0.05
Western blot of LKB1 expression increased in the carotid artery balloon injury model compared to the control group.
Positive_regulation (increased) of Gene_expression (expression) of LKB1 in carotid artery associated with injury
10) Confidence 0.49 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.20 Pain Relevance 0
There might be some mechanisms which interfere with increased LKB1 expression and kinase activity.
Positive_regulation (increased) of Gene_expression (expression) of LKB1
11) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.37 Pain Relevance 0
However, increased LKB1 expression was not correlated with LKB1 activity in the balloon-injured carotid artery.
Positive_regulation (increased) of Gene_expression (expression) of LKB1 in carotid artery
12) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.01 Pain Relevance 0
Balloon injury increased the expression of LKB1 although LKB1 activity was reduced.
Positive_regulation (increased) of Gene_expression (expression) of LKB1 associated with injury
13) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.04 Pain Relevance 0
AMPK activation suppresses protein synthesis and prevents cardiac myocyte hypertrophy by regulation of the eEF2 kinase/eEF2 axis and/or TSC2-mTOR-P70S6 pathways.22-24) LKB1 has been reported to cause G1 growth arrest in cultured cells via induction of p21WAF1/CIP111) and stimulation of Brg1 ATPase.25) LKB1 kinase activity is required for p21WAF1/CIP1 induction, and overexpression of LKB1 causes p21WAF1/CIP1-induced growth arrest in cells with undetectable or low levels of endogenous LKB1.11) In contrast to kinase activity, although Brg1-associated growth arrest also requires LKB1 kinase activity, wild-type LKB1 and the kinase-deficient form LKB1-SL26 both stimulate Brg1 ATPase.25) This suggests that some regulatory functions of LKB1 may not require its kinase activity.19) As is well known, LKB1 has an autophosphorylation activity to increased its kinase activity.
Positive_regulation (overexpression) of Gene_expression (overexpression) of LKB1 in cardiac myocyte associated with hypertrophy
14) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.28 Pain Relevance 0
Our data showed that Ang II induces LKB1 expression in VSMCs and that LKB1 expression increased after vascular injury.
Positive_regulation (increased) of Gene_expression (expression) of LKB1 associated with vasculitis
15) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.31 Pain Relevance 0
In this study, we demonstrated the increased expression of LKB1 in the VSMCs by Ang II and neointima of injured rat carotid artery.
Positive_regulation (increased) of Gene_expression (expression) of LKB1 in carotid artery associated with neointima
16) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.91 Pain Relevance 0
Increased LKB1 expression started at 5 days after the balloon injury, and peaked at 14 days after the injury.
Positive_regulation (Increased) of Gene_expression (expression) of LKB1 associated with injury
17) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC3008825 Disease Relevance 1.31 Pain Relevance 0
Also, LKB1 expression was significantly increased in neointima.
Positive_regulation (increased) of Gene_expression (expression) of LKB1 associated with neointima
18) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.02 Pain Relevance 0
Although LKB1 expression was increased after the injury, LKB1 kinase activity was not increased.
Positive_regulation (increased) of Gene_expression (expression) of LKB1 associated with injury
19) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC3008825 Disease Relevance 1.29 Pain Relevance 0
Overexpressed LKB1 increases expression of several p21 (CDK inhibitor), p53 responsive genes.8-11) This tumor suppressor protein may have an important role in atherosclerosis, especially in restenosis.
Positive_regulation (Overexpressed) of Gene_expression (Overexpressed) of LKB1 associated with cardiovascular disease, cancer and increased venous pressure under development
20) Confidence 0.45 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.73 Pain Relevance 0

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