INT351970

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Context Info
Confidence 0.75
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 39
Disease Relevance 33.89
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Stk11) mitochondrion (Stk11) nucleus (Stk11)
cell cycle (Stk11) protein complex (Stk11) cytoplasm (Stk11)
Anatomy Link Frequency
carotid artery 6
aorta 2
cardiac myocyte 1
smooth muscle cells 1
Stk11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 78 95.92 Very High Very High Very High
anesthesia 39 37.24 Quite Low
ketamine 39 34.32 Quite Low
Disease Link Frequency Relevance Heat
Injury 819 99.70 Very High Very High Very High
Cancer 429 99.48 Very High Very High Very High
Neointima 819 99.44 Very High Very High Very High
Vasculitis 234 99.32 Very High Very High Very High
Carotid Artery Injuries 195 98.44 Very High Very High Very High
Necrosis 39 94.80 High High
Increased Venous Pressure Under Development 78 94.36 High High
Hypertrophy 39 94.34 High High
Cardiovascular Disease 234 93.12 High High
Congenital Anomalies 39 90.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry showed increased LKB1 expression after the carotid artery balloon injury compared to the control group (Fig. 2D and E).
Gene_expression (expression) of LKB1 in carotid artery associated with injury
1) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.34 Pain Relevance 0.03
Western blot of LKB1 expression increased in the carotid artery balloon injury model compared to the control group.
Gene_expression (expression) of LKB1 in carotid artery associated with injury
2) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.20 Pain Relevance 0
Ang II augmented the increased expression of LKB1 (Fig. 2F).
Gene_expression (expression) of LKB1
3) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.31 Pain Relevance 0.03
First, we failed to transfect LKB1 to evaluate the direct effect of LKB1, with or without AII stimulation, on proliferation of VSMC in vitro and in vivo.
Neg (failed) Gene_expression (transfect) of LKB1
4) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.32 Pain Relevance 0
The LKB1 expression peaked at an Ang II concentration of 10-7 mole/L and then decreased at an Ang II concentration of 10-5 mole/L (Fig. 1B).
Gene_expression (expression) of LKB1
5) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.84 Pain Relevance 0.04
We found increased expression of LKB1 under Ang II stimulated conditions.
Gene_expression (expression) of LKB1
6) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.51 Pain Relevance 0.05
LKB1 expression increased in neointima of balloon-injured carotid arteries
Gene_expression (expression) of LKB1 associated with neointima
7) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.05 Pain Relevance 0.04
Expression of LKB1 was graded according to the following scale by two investigators blinded to the experimental conditions: negative (0), mild staining (1), moderate staining (2), and intense staining (3).


Gene_expression (Expression) of LKB1
8) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.11 Pain Relevance 0.03
In conclusion, LKB1 was expressed in the VSMCs and neointima.
Gene_expression (expressed) of LKB1 associated with neointima
9) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.83 Pain Relevance 0
Although endogenous Ang II increased after vascular injury, the mechanisms of the interaction between Ang II, increased LKB1 expression and decreased LKB1 kinase activity is still elusive.
Gene_expression (expression) of LKB1 associated with vasculitis
10) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.67 Pain Relevance 0
Angiotensin II increased LKB1 expression in vascular smooth muscle cells
Gene_expression (expression) of LKB1 in smooth muscle cells
11) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.33 Pain Relevance 0.05
Serial LKB1 staining showed LKB1 expression increased 5 days after the balloon injury and peaked 14 days after the injury according to neointima formation (Fig. 3).


Gene_expression (expression) of LKB1 associated with injury and neointima
12) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.24 Pain Relevance 0
Since LKB1 activity is dependent on post-translational modification, such as phosphorylation or acetylation, further study is needed to elucidate the molecular mechanisms of how Ang II increases LKB1 expression and decreases activity in VSMC and neointima formation.
Gene_expression (expression) of LKB1 associated with neointima
13) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.80 Pain Relevance 0
Ang II increased the LKB1 expression showed a bell shaped curve.
Gene_expression (expression) of LKB1
14) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.71 Pain Relevance 0.04
Ang II augmented the increased expression of LKB1.
Gene_expression (expression) of LKB1
15) Confidence 0.75 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.19 Pain Relevance 0
Ang II increases tumor suppressor serine/threonine kinase LKB1 expression in the VSMCs and neointima of the rat carotid artery injury model.
Gene_expression (expression) of kinase LKB1 in carotid artery associated with carotid artery injuries, cancer and neointima
16) Confidence 0.65 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.79 Pain Relevance 0
LKB1 western blot
Gene_expression (blot) of LKB1
17) Confidence 0.65 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.07 Pain Relevance 0.04
The amount of LKB1 protein was not correlated with LKB1 kinase activity in balloon-injured carotid arteries
Gene_expression (amount) of LKB1 protein
18) Confidence 0.65 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.20 Pain Relevance 0
However, increased LKB1 expression was not correlated with LKB1 kinase activity in the balloon-injured carotid arteries.
Gene_expression (expression) of LKB1
19) Confidence 0.58 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 0.30 Pain Relevance 0
We assessed the association of Ang II and the expression of LKB1 in primary cultured murine VSMCs and neointima of the Sprague Dawley rat carotid artery injury model.
Gene_expression (expression) of LKB1 in carotid artery associated with carotid artery injuries and neointima
20) Confidence 0.58 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC3008825 Disease Relevance 0.94 Pain Relevance 0

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