INT351976

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tp53, Stk11) protein complex (Tp53, Stk11) cytoplasm (Tp53, Stk11)
cytosol (Tp53, Stk11) nucleus (Tp53, Stk11) nucleoplasm (Tp53)
Tp53 (Rattus norvegicus)
Stk11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 4 99.16 Very High Very High Very High
Cancer 22 99.08 Very High Very High Very High
Hypoxia 2 98.28 Very High Very High Very High
Stress 2 96.40 Very High Very High Very High
Cardiovascular Disease 12 95.76 Very High Very High Very High
Increased Venous Pressure Under Development 4 94.68 High High
Neointima 42 86.72 High High
Carotid Artery Injuries 10 83.84 Quite High
Injury 42 79.36 Quite High
Congenital Anomalies 2 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LKB1 interacts with the p53 pathway, suppresses cellular proliferation, and has a proapoptotic effect.8)11-13) These findings support the hypothesis that LKB1 protein kinase functions regulate cellular proliferation as a tumor suppressor.
p53 Binding (interacts) of LKB1 associated with cancer and hyperplasia
1) Confidence 0.13 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.51 Pain Relevance 0
LKB1, a serine/threonine kinase, interacts with the p53 pathway and acts as a tumor suppressor.


p53 Binding (interacts) of LKB1 associated with cancer
2) Confidence 0.10 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC3008825 Disease Relevance 0.79 Pain Relevance 0

General Comments

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