INT352045

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.80
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cd48) plasma membrane (Cd48) protein complex (Cd48)
Anatomy Link Frequency
body 3
skull 1
brain 1
Cd48 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 12 90.36 High High
Inflammation 132 89.32 High High
cva 18 88.60 High High
Deafferentation 6 23.84 Low Low
medulla 30 7.44 Low Low
imagery 54 5.00 Very Low Very Low Very Low
ischemia 18 5.00 Very Low Very Low Very Low
Catecholamine 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Injury 114 99.96 Very High Very High Very High
Heart Rate Under Development 36 95.16 Very High Very High Very High
Sleep Disorders 18 94.68 High High
Injury 198 94.64 High High
Pressure Volume 2 Under Development 18 94.24 High High
INFLAMMATION 138 89.32 High High
Cv General 3 Under Development 18 88.60 High High
Pressure And Volume Under Development 48 79.64 Quite High
Urological Neuroanatomy 84 73.48 Quite High
Penetrating Head Injuries 6 69.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primary blast envelops the whole body, and interacts with all organs and organ systems, including the brain, simultaneously (Cernak and Noble-Haeusslein, 2010).
blast Binding (interacts) of in brain
1) Confidence 0.05 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009449 Disease Relevance 0.56 Pain Relevance 0.03
This second, indirect interactive pathway is unique for BINT, and underlies its immense complexity as compared to non-blast TBI.


blast Binding (complexity) of associated with brain injury
2) Confidence 0.04 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009449 Disease Relevance 0.28 Pain Relevance 0
Blast-induced neurotrauma is caused by multiple, interwoven mechanisms of systemic, local, and cerebral responses to blast exposure, often interacting with the body simultaneously (Cernak et al., 1991, 1996b; Cernak and Noble-Haeusslein, 2010; Figure 1).
Blast Binding (interacting) of in body
3) Confidence 0.04 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009449 Disease Relevance 0.24 Pain Relevance 0
Clinical experience suggests specific blast–body–nervous system interactions such as (1) direct interaction with the head either through direct passage of the blast wave through the skull or by causing acceleration and/or rotation of the head; and (2) via hydraulic interaction, when the blast overpressure compresses the abdomen and chest, and transfers its kinetic energy to the body's fluid phase, initiating oscillating waves that traverse the body and reach the brain.
blast Binding (interaction) of in skull
4) Confidence 0.04 Published 2010 Journal Frontiers in Neurology Section Abstract Doc Link PMC3009449 Disease Relevance 0.43 Pain Relevance 0.03
Taken together, the results of our study clearly demonstrate the importance of the indirect, i.e., blast–body interaction as well as the decisive role of autonomous nervous–neuroendocrine–immune systems interaction in the pathogenesis of BINT.


blast Binding (interaction) of in body
5) Confidence 0.04 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009449 Disease Relevance 0.96 Pain Relevance 0.19
The Importance of Systemic Response in the Pathobiology of Blast-Induced Neurotrauma

Due to complex injurious environment where multiple blast effects interact with the body parallel, blast-induced neurotrauma is a unique clinical entity induced by systemic, local, and cerebral responses.

blast Binding (interact) of in body
6) Confidence 0.04 Published 2010 Journal Frontiers in Neurology Section Title Doc Link PMC3009449 Disease Relevance 0.31 Pain Relevance 0

General Comments

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