INT352048

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.28
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Spns1) transmembrane transport (Spns1)
Anatomy Link Frequency
sympathetic 2
nerve 1
spinal cord 1
Spns1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 64 99.32 Very High Very High Very High
Central nervous system 4 88.28 High High
GABAergic 68 87.84 High High
Intracerebroventricular 4 87.20 High High
agonist 44 86.64 High High
intrathecal 4 81.64 Quite High
medulla 4 78.48 Quite High
Pyramidal cell 8 67.48 Quite High
excitatory amino acid 4 52.28 Quite High
adenocard 12 40.80 Quite Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 4 90.60 High High
Urological Neuroanatomy 60 72.48 Quite High
Decapitation 4 59.28 Quite High
Pain 4 7.44 Low Low
Epilepsy 4 6.76 Low Low
Depression 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Hypotension 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore the intriguing possibility of GABAB receptors with specific sensitivities to baclofen prompted us to determine how very low concentrations of baclofen affects both pre- and postsynaptic GABAB receptors on SPNs in the thoracic spinal cord slice preparation.


Regulation (affects) of SPNs in spinal cord associated with spinal cord
1) Confidence 0.14 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.06 Pain Relevance 0.15
At the level of the spinal cord, the sympathetic preganglionic neurons (SPNs) can be modulated by activation of presynaptic GABAB heteroreceptors on glutamatergic terminals and by postsynaptic GABAB receptors.
Regulation (modulated) of SPNs in sympathetic associated with spinal cord
2) Confidence 0.10 Published 2010 Journal Frontiers in Neurology Section Abstract Doc Link PMC3009458 Disease Relevance 0 Pain Relevance 0.13
In a spinal cord–splanchnic nerve preparation, bath application of baclofen suppresses splanchnic nerve activities possibly via two mechanisms: direct inhibition of membrane excitability by affecting K+ or Ca2+ currents and/or attenuation of excitatory synaptic events to SPNs (Cheng et al., 2005).
Regulation (affecting) of SPNs in nerve associated with spinal cord
3) Confidence 0.10 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.16 Pain Relevance 0.24
Continuing research into the spinal cord circuitry that regulates sympathetic output has revealed a high degree of complexity of control of these SPNs which enables fine tuning of the sympathetic activity influencing end organs.
Regulation (control) of SPNs in sympathetic associated with spinal cord
4) Confidence 0.06 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.06 Pain Relevance 0.29

General Comments

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