INT352049

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.39
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Spns1) transmembrane transport (Spns1)
Anatomy Link Frequency
spinal cord 1
interneurons 1
Spns1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 48 98.04 Very High Very High Very High
gABA 12 93.80 High High
potassium channel 9 92.40 High High
agonist 33 82.40 Quite High
GABAergic 51 77.64 Quite High
antagonist 36 72.84 Quite High
Glutamate receptor 6 54.76 Quite High
Rostral ventrolateral medulla 3 50.40 Quite High
Calcium channel 9 26.80 Quite Low
depression 3 22.68 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 45 97.72 Very High Very High Very High
Hypotension 3 37.92 Quite Low
Depression 3 22.68 Low Low
Decapitation 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Epilepsy 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of tonic GABAB activation on SPNs has also been reported using a splanchnic nerve–spinal cord preparation (Cheng et al., 2005).


Positive_regulation (activation) of SPNs in spinal cord associated with spinal cord
1) Confidence 0.18 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.12 Pain Relevance 0.35
Distinct postsynaptic responses to low concentrations of baclofen in SPNs
Positive_regulation (responses) of SPNs
2) Confidence 0.11 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.17 Pain Relevance 0.32
Secondly, very low concentrations of baclofen induced a number of responses in SPNs and also hyperpolarized interneurons – differences in responses may be due to the second messenger systems mediating these responses.
Positive_regulation (induced) of SPNs in interneurons
3) Confidence 0.10 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.10 Pain Relevance 0.29

General Comments

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