INT352062

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.70
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (SV2A, Chrna7) signal transduction (Chrna7) transmembrane transporter activity (SV2A)
endoplasmic reticulum (SV2A) plasma membrane (Chrna7)
Anatomy Link Frequency
muscle 1
SV2A (Homo sapiens)
Chrna7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 1 84.08 Quite High
Action potential 1 48.16 Quite Low
gABA 1 36.72 Quite Low
GABA receptor 1 34.72 Quite Low
Spinal cord 6 34.68 Quite Low
agonist 1 14.00 Low Low
Central nervous system 2 9.68 Low Low
hyperexcitability 3 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spasticity 31 96.44 Very High Very High Very High
Cerebral Palsy 1 72.48 Quite High
Muscle Hypertonia 1 70.36 Quite High
Contracture 1 66.32 Quite High
Hypersensitivity 1 49.28 Quite Low
Shock 1 22.04 Low Low
Syndrome 5 5.00 Very Low Very Low Very Low
Aids-related Complex 2 5.00 Very Low Very Low Very Low
Muscular Spasm 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When injected at or near the motor point of affected muscle BTX binds to the SV2 receptor on the presynaptic membrane allowing for entry of the toxin into the axon terminal.
SV2 receptor Binding (binds) of BTX in muscle
1) Confidence 0.00 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009478 Disease Relevance 0.70 Pain Relevance 0.04

General Comments

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