INT35208

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Context Info
Confidence 0.49
First Reported 1980
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.08
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
pituitary 2
midbrain 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
midbrain 2 95.96 Very High Very High Very High
Raphe 4 94.60 High High
noradrenaline 1 91.20 High High
Dopamine 3 90.00 High High
Serotonin 1 88.96 High High
anesthesia 3 79.24 Quite High
monoamine 1 75.00 Quite High
Neurotransmitter 1 62.56 Quite High
Clonidine 2 50.08 Quite High
agonist 2 47.52 Quite Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 1 84.40 Quite High
Hypoglycemia 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The administration of gamma-hydroxybutyrate (GHB) induced a consistent secretory episode of growth hormone (GH) in the morning followed by basal levels of secretion of GH for several hours.
Positive_regulation (induced) of Negative_regulation (episode) of GH
1) Confidence 0.49 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7430898 Disease Relevance 0 Pain Relevance 0.30
Suppression of human growth hormone (GH)-releasing hormone-induced GH secretion in pentobarbital-anesthetized rats after electrical stimulation of the midbrain central gray and several raphe nuclei.
Positive_regulation (-releasing) of Negative_regulation (Suppression) of GH in midbrain associated with midbrain and raphe
2) Confidence 0.48 Published 1988 Journal Endocrinology Section Title Doc Link 3123202 Disease Relevance 0 Pain Relevance 0.34
These data indicate that GH responsiveness to hpGRF is: enhanced in the anterior pituitary shortly after hypothalamo-pituitary disconnection and, despite a striking reduction of the pituitary GH stores, it is maintained after these lesions.
Positive_regulation (enhanced) of Negative_regulation (reduction) of GH in pituitary
3) Confidence 0.24 Published 1984 Journal Life Sci. Section Abstract Doc Link 6436609 Disease Relevance 0.08 Pain Relevance 0.07

General Comments

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