INT3521

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Context Info
Confidence 0.54
First Reported 1976
Last Reported 2010
Negated 5
Speculated 2
Reported most in Body
Documents 38
Total Number 41
Disease Relevance 11.09
Pain Relevance 12.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
CSF 10
liver 2
neuronal 2
macrophages 1
tibia 1
Csf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 38 100.00 Very High Very High Very High
Morphine 35 100.00 Very High Very High Very High
Gabapentin 15 100.00 Very High Very High Very High
cINOD 2 100.00 Very High Very High Very High
Lasting pain 10 99.98 Very High Very High Very High
Glutamate 174 99.96 Very High Very High Very High
excitatory amino acid 13 99.96 Very High Very High Very High
Deafferentation 2 99.92 Very High Very High Very High
Nerve growth factor 54 99.82 Very High Very High Very High
tolerance 6 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hydrocephalus 85 100.00 Very High Very High Very High
Nociception 9 100.00 Very High Very High Very High
Pain 20 99.98 Very High Very High Very High
Aging 2 99.98 Very High Very High Very High
Hypercalcemia 4 99.84 Very High Very High Very High
Stroke 77 99.48 Very High Very High Very High
Disease 103 98.40 Very High Very High Very High
Syndrome 8 98.20 Very High Very High Very High
Injury 54 97.96 Very High Very High Very High
Arachnoid Cysts 44 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Riluzole, guanosine, and MK-801 (0.01 or 0.1 mg/kg) did not affect basal nociceptive responses or CSF EAAs levels.
Neg (not) Regulation (affect) of CSF associated with nociception and excitatory amino acid
1) Confidence 0.54 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18854198 Disease Relevance 0.75 Pain Relevance 1.45
In this study, the effects of the NSAID naproxen sodium, G-CSF, and both of them in combination on the TGF-beta1 serum level in rats with tibia fractures were measured and fracture healing was evaluated by histopathologic and radiologic examination.
Regulation (effects) of G-CSF in tibia associated with fracture healing, cinod and tibia fractures
2) Confidence 0.50 Published 2006 Journal Life Sci. Section Abstract Doc Link 17023006 Disease Relevance 0.55 Pain Relevance 0.29
To further investigate the neuromodulatory effect of GM-CSF we studied the influence of GM-CSF on the efferent electric activity in the splenic nerve and the integral neuronal activity in medullary gigantocellular reticular formation (MGRF) in rats.
Spec (investigate) Regulation (effect) of GM-CSF in neuronal
3) Confidence 0.45 Published 2004 Journal Neuroimmunomodulation Section Abstract Doc Link 14557677 Disease Relevance 0 Pain Relevance 0.09
To further investigate the neuromodulatory effect of GM-CSF we studied the influence of GM-CSF on the efferent electric activity in the splenic nerve and the integral neuronal activity in medullary gigantocellular reticular formation (MGRF) in rats.
Regulation (influence) of GM-CSF in neuronal
4) Confidence 0.45 Published 2004 Journal Neuroimmunomodulation Section Abstract Doc Link 14557677 Disease Relevance 0 Pain Relevance 0.09
Eighty male Sprague-Dawley rats were randomized into four groups. (1) control, (2) steroid, (3) steroid + local GM-CSF, (4) steroid + systemic GM-CSF.
Regulation (control) of GM-CSF
5) Confidence 0.45 Published 2002 Journal World J Surg Section Abstract Doc Link 12205560 Disease Relevance 0.51 Pain Relevance 0.33
CONCLUSION: It was found that noxious stimulus from the tooth pulp is not a factor affecting significantly AVP and OT release into CSF.


Neg (not) Regulation (affecting) of CSF in CSF
6) Confidence 0.43 Published 2007 Journal Endocr Regul Section Body Doc Link 18257651 Disease Relevance 0.06 Pain Relevance 0
Our results demonstrate a local in vivo effect of LPS and of M-CSF on bone resorption and suggest that these substances act at different stages of osteoclast development and function.
Regulation (effect) of M-CSF in osteoclast associated with hypercalcemia
7) Confidence 0.43 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8460686 Disease Relevance 0.33 Pain Relevance 0.07
The above mentioned experimental evidences prompted us to compare the effects of the administration of rhEPO, GM-CSF and their combination on liver regeneration following major hepatectomy.
Regulation (effects) of GM-CSF in liver
8) Confidence 0.42 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.36 Pain Relevance 0.12
Aim of the present study is to compare the effect of the administration of EPO and GM-CSF alone or in combination on the acceleration of liver regeneration in rats after major hepatectomy.


Regulation (effect) of GM-CSF in liver
9) Confidence 0.42 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.20 Pain Relevance 0.14
Normally, ependymal cells form a pseudostratified monolayer of epithelium that regulates fluid and electrolyte balance between the CSF and neuropil [39].
Regulation (regulates) of CSF in neuropil
10) Confidence 0.38 Published 2007 Journal BMC Neurol Section Body Doc Link PMC2018707 Disease Relevance 0.36 Pain Relevance 0.10
The relative capacity of this basolateral efflux mechanism, favoring PGE2 elimination in blood and thus supplementing the enzymatic signal termination mechanism needs to be established by comparison to uptake and metabolism in order to delineate how CSF-borne PGE2 concentration is controlled in developing animals.
Regulation (controlled) of CSF in blood
11) Confidence 0.36 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2292143 Disease Relevance 0.21 Pain Relevance 0.07
Our results therefore suggest that in vivo, centrally released PGE2 that circulates in CSF will be metabolized to some extent by choroidal metabolizing enzymes.
Regulation (metabolized) of CSF
12) Confidence 0.36 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2292143 Disease Relevance 0 Pain Relevance 0
The NMDA effect [5,7] was evaluated using the following procedure: we first determined the concentrations of glutamate in 4 successive samples starting 60 minutes after infusion of a control solution (CSF from neurological patients without NMDA-R Ab) or patients' CSF (volume of 5 ?
Regulation (control) of CSF associated with glutamate
13) Confidence 0.36 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3002330 Disease Relevance 0 Pain Relevance 0.27
The NMDA effect [5,7] was evaluated using the following procedure: we first determined the concentrations of glutamate in 4 successive samples starting 60 minutes after infusion of a control solution (CSF from neurological patients without NMDA-R Ab) or patients' CSF (volume of 5 ?
Regulation (control) of CSF associated with glutamate
14) Confidence 0.36 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3002330 Disease Relevance 0 Pain Relevance 0.27
The effect of GBP and morphine on CSF glutamate and aspartate levels was examined in naïve rats, and the effect of morphine challenge on CSF glutamate and aspartate levels was examined in rats previously infused for 5 days with morphine alone or morphine plus GBP.
Regulation (effect) of CSF associated with glutamate, gabapentin and morphine
15) Confidence 0.31 Published 2005 Journal Brain Res. Section Abstract Doc Link 16054118 Disease Relevance 0 Pain Relevance 3.38
Previously we have shown a strong influence of G-CSF on functional outcome in the cortical photothrombotic model [6].
Regulation (influence) of G-CSF
16) Confidence 0.27 Published 2006 Journal BMC Biol Section Body Doc Link PMC1633735 Disease Relevance 0.48 Pain Relevance 0.17
The strong effects on functional outcome distuinguish G-CSF from most other candidate stroke drugs in development.
Regulation (effects) of G-CSF associated with stroke
17) Confidence 0.27 Published 2006 Journal BMC Biol Section Body Doc Link PMC1633735 Disease Relevance 0.83 Pain Relevance 0.13
Changes in CSF LH-RH generally paralleled the hypothalamic changes; ether, for example, elicited a significant rise.
Regulation (Changes) of CSF LH-RH in CSF
18) Confidence 0.27 Published 1976 Journal Neuroendocrinology Section Abstract Doc Link 785296 Disease Relevance 0 Pain Relevance 0.21
RESULTS: The concentrations of AVP-LI and OT-LI in CSF were found to reach 21 pg/ml and 67 pg/ml, respectively.
Regulation (concentrations) of CSF in CSF
19) Confidence 0.26 Published 2007 Journal Endocr Regul Section Body Doc Link 18257651 Disease Relevance 0.07 Pain Relevance 0
CSF samples collected from the cisterna magna during the late embryonic life (E18, E19, E20) and the early postnatal life (PN1, PN7) displayed a very similar pattern of AFRU-immunoreactive bands (Fig. 2E).
Regulation (collected) of CSF in bands
20) Confidence 0.25 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2265671 Disease Relevance 0 Pain Relevance 0.03

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