INT35210

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2010
Negated 7
Speculated 3
Reported most in Body
Documents 39
Total Number 42
Disease Relevance 6.00
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ghsr) signal transducer activity (Ghsr)
Anatomy Link Frequency
testis 4
pituitary 4
arcuate nucleus 3
OSE 2
interstitial cells 2
Ghsr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 6 100.00 Very High Very High Very High
Intracerebroventricular 4 99.48 Very High Very High Very High
Neuropeptide 12 98.92 Very High Very High Very High
Ventral tegmentum 8 96.16 Very High Very High Very High
agonist 69 92.72 High High
Nucleus accumbens 8 86.32 High High
Inflammation 168 86.16 High High
Morphine 14 82.32 Quite High
Enkephalin 33 82.00 Quite High
medulla 29 79.76 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 46 99.96 Very High Very High Very High
Diabetes Mellitus 379 98.88 Very High Very High Very High
Apoptosis 37 98.72 Very High Very High Very High
Aids-related Complex 54 96.08 Very High Very High Very High
Hyperplasia 147 95.24 Very High Very High Very High
Injury 31 94.16 High High
Thyroid Disease 8 91.12 High High
Rupture 27 89.76 High High
INFLAMMATION 170 86.16 High High
Body Weight 58 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of ghrelin receptor in the rat testis has also been shown to be up-regulated around the time of pubertal gonad development [30].
Gene_expression (expression) of ghrelin receptor in gonad
1) Confidence 0.75 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.10 Pain Relevance 0
In rats, it is known that the fetus and placenta secrete ghrelin, and that the ghrelin receptor is present in fetal tissues [32-35].
Gene_expression (present) of ghrelin receptor in placenta
2) Confidence 0.75 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.15 Pain Relevance 0
Ghrelin and its receptor are present in the human testis, but in contrast to the ovine data, ghrelin protein is not detectable in germ cells at any stage of spermatogenesis [21].
Neg (not) Gene_expression (detectable) of ghrelin protein in testis
3) Confidence 0.75 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.12 Pain Relevance 0.06
Gaytan and colleagues [14] have suggested a potential, yet unproven relationship between GHSR-1a expression and follicle growth, since expression of the receptor in somatic cells derived from ovarian follicles roughly parallels follicular development in the human ovary.
Gene_expression (expression) of GHSR in somatic cells
4) Confidence 0.75 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.23 Pain Relevance 0.06
In the sheep anterior pituitary gland, ghrelin and GHSR-1a were ubiquitously expressed.
Gene_expression (expressed) of GHSR in gland
5) Confidence 0.75 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0.15
In the fetal sheep testis, the present findings indicate that the expression of ghrelin and GHSR-1a protein is linked to gestational age.
Gene_expression (expression) of GHSR in testis
6) Confidence 0.75 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
Testicular GHSR-1a gene expression
Gene_expression (expression) of GHSR
7) Confidence 0.75 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
Similarly, an immunohistochemical study in rats by Lin et al. [54] revealed that the GHSR-1a was expressed in the neuronal cells of the NTS and the dorsal motor nucleus of the vagus, but not in the cells of the area postrema.
Neg (not) Gene_expression (expressed) of GHSR in area postrema
8) Confidence 0.75 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.06 Pain Relevance 0.07
We have now studied GHRP-6-induced GH and PRL release and their regulation by estrogen (E2) in anesthetized male and female rats and in GH-deficient dwarf (dw/dw) rats that maintain high pituitary PRL stores and show elevated hypothalamic GH secretagogue receptor expression.
Gene_expression (expression) of GH secretagogue receptor in pituitary
9) Confidence 0.70 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
The increased PRL response could reflect an increase in GH secretagogue receptor expression that was observed in the arcuate and ventromedial nuclei of E2-treated rats.
Gene_expression (expression) of GH secretagogue receptor
10) Confidence 0.70 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
Ghrelin receptor (GHSR-1a) and PCNA immunoreactivity were detected using the Vectastain Elite ABC kit (Vector Laboratories Ltd, Peterborough, UK) The protocol was as described above with exception of the following: the secondary antibody was a biotinylated rabbit anti-goat IgG (Vector Laboratories Ltd, Peterborough, UK) in a 1:200 dilution.
Gene_expression (detected) of Ghrelin receptor
11) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
From day 70 onwards, positive staining for GHSR-1a was restricted to the Sertoli and interstitial cells (Fig. 6j,n)
Gene_expression (staining) of GHSR in interstitial cells
12) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
In the sheep hindbrain, ghrelin and GHSR-1a immunostaining was also identified in neuronal cell bodies within the nucleus tract solitarus (NTS), but not in the area postrema.
Neg (not) Gene_expression (identified) of GHSR in neuronal
13) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.07 Pain Relevance 0.06
There was general immunopositive staining for ghrelin and GHSR-1a throughout hypothalamic region of the brain, including the median eminence (ME), arcuate nucleus (ARC), ventromedial hypothalamus (VMH) and ependymal lining (EL) of the third cerebral ventricle (Fig. 2).
Gene_expression (staining) of GHSR in arcuate nucleus associated with aids-related complex
14) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.10 Pain Relevance 0
Ghrelin receptor (GHSR-1a) and PCNA immunoreactivity were detected using the Vectastain Elite ABC kit (Vector Laboratories Ltd, Peterborough, UK) The protocol was as described above with exception of the following: the secondary antibody was a biotinylated rabbit anti-goat IgG (Vector Laboratories Ltd, Peterborough, UK) in a 1:200 dilution.
Gene_expression (detected) of GHSR
15) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
Ghrelin and GHSR-1a were also present in the hindbrain where they were found in distinct neuronal bodies in the nucleus tract solitarus (NTS).
Gene_expression (present) of GHSR in neuronal
16) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.10 Pain Relevance 0
Ghrelin and GHSR-1a immunostaining was also present in the luteal cells of the corpus luteum.
Gene_expression (present) of GHSR in luteal cells
17) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.06 Pain Relevance 0
The GHSR-1a and SCF positive cells both exhibited cytoplasmic staining.


Gene_expression (staining) of GHSR
18) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.08 Pain Relevance 0
This pattern contrasted with those of untreated and GHRP-6 treated somatotropes which each produced unimodal frequency distributions that were skewed to the left (toward smaller plaques) and were virtually superimposable at the end of a 4 h incubation.
Gene_expression (produced) of GHRP-6 in plaques
19) Confidence 0.61 Published 1988 Journal Life Sci. Section Abstract Doc Link 3123835 Disease Relevance 0 Pain Relevance 0.08
The purpose of this study was to determine the effect of intracerebroventricular (i.c.v.) injections of a synthetic, opioid-related hexapeptide, growth-hormone-releasing peptide-6 (GHRP-6), on stimulation of eating by rats and to correlate this aspect of feeding behavior with the peripheral plasma growth hormone (GH) response to the administered peptide.
Gene_expression (synthetic) of GHRP-6 in plasma associated with opioid and intracerebroventricular
20) Confidence 0.59 Published 1995 Journal Life Sci. Section Abstract Doc Link 8614257 Disease Relevance 0 Pain Relevance 0.19

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