INT35211

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Context Info
Confidence 0.31
First Reported 1988
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 0
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ghsr, Gh1) mitochondrion (Gh1) signal transducer activity (Ghsr)
cytosol (Gh1) extracellular space (Gh1) signal transduction (Gh1)
Anatomy Link Frequency
somatotropes 8
neurons 2
pituitary 2
Ghsr (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 4 75.00 Quite High
Enkephalin 1 62.40 Quite High
tetrodotoxin 3 46.64 Quite Low
Action potential 3 25.00 Low Low
anesthesia 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ghrelin is an endogenous growth hormone secretagogue (GHS) causing release of GH from pituitary somatotropes through the GHS receptor.
GHS Positive_regulation (causing) of Localization (release) of GH in somatotropes
1) Confidence 0.31 Published 2005 Journal Endocrine Section Abstract Doc Link 16388096 Disease Relevance 0 Pain Relevance 0
Taken together, these results suggest that GHRP-6 causes the immediate release of a limited pool of GH which is present only in a discrete subpopulation of somatotropes that respond to GRF.
GHRP-6 Positive_regulation (causes) of Localization (release) of GH in somatotropes
2) Confidence 0.31 Published 1988 Journal Life Sci. Section Abstract Doc Link 3123835 Disease Relevance 0 Pain Relevance 0.06
Ghrelin is an endogenous growth hormone secretagogue (GHS) causing release of GH from pituitary somatotropes through the GHS receptor.
GHS Positive_regulation (causing) of Localization (release) of GH in somatotropes
3) Confidence 0.25 Published 2005 Journal Endocrine Section Abstract Doc Link 16388096 Disease Relevance 0 Pain Relevance 0
Ghrelin is an endogenous growth hormone secretagogue (GHS) causing release of GH from pituitary somatotropes through the GHS receptor.
growth hormone secretagogue Positive_regulation (causing) of Localization (release) of GH in somatotropes
4) Confidence 0.25 Published 2005 Journal Endocrine Section Abstract Doc Link 16388096 Disease Relevance 0 Pain Relevance 0
Growth hormone secretagogues (GHS) administered systemically selectively induce growth hormone (GH) release from the pituitary and the expression of Fos protein in arcuate nucleus neurons.
GHS Positive_regulation (induce) of Localization (release) of GH in neurons
5) Confidence 0.24 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10461024 Disease Relevance 0 Pain Relevance 0.15
These effects could be dissociated from GHRP-6-induced GH release in the same animals, but not from PRL release induced by TRH, which was also abolished by ovariectomy and induced in males by E2 treatment.
GHRP-6-induced Positive_regulation (induced) of Localization (release) of GH
6) Confidence 0.19 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
We have now studied GHRP-6-induced GH and PRL release and their regulation by estrogen (E2) in anesthetized male and female rats and in GH-deficient dwarf (dw/dw) rats that maintain high pituitary PRL stores and show elevated hypothalamic GH secretagogue receptor expression.
GHRP-6-induced Positive_regulation (induced) of Localization (release) of GH in pituitary
7) Confidence 0.19 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0

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