INT352131

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.17
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bcl2l11) mitochondrion (Bcl2l11) cytoplasm (Bcl2l11)
Bcl2l11 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 15 98.90 Very High Very High Very High
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 130 100.00 Very High Very High Very High
Epstein-barr Virus 145 98.96 Very High Very High Very High
Suicidal Behaviour 10 85.28 High High
Lymphatic System Cancer 45 81.16 Quite High
Viral Infection 5 79.84 Quite High
Disease 20 77.60 Quite High
Cancer 35 77.36 Quite High
Death 35 72.88 Quite High
Nasopharynx Cancer 15 72.88 Quite High
B-cell Lymphoma 5 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the BHRF1:Bim complex, a heavy atom derivative was obtained by soaking crystals in mother liquor supplemented with 1 mM MeHgCl for 2 h.
Bim Binding (complex) of
1) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009601 Disease Relevance 0 Pain Relevance 0
BHRF1 acts by sequestering a subset of the pro-apoptotic Bcl-2 family proteins; we show here the 3D structures of it in complex with BH3 domains of two, Bim and Bak, which may provide the basis for developing small molecule inhibitors of BHRF1 to improve the generally poor prognosis in EBV-associated malignancies.


Bim Binding (complex) of associated with epstein-barr virus and apoptosis
2) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009601 Disease Relevance 1.08 Pain Relevance 0
As current small organic antagonists of Bcl-2 do not target BHRF1, the structures of it in complex with Bim or Bak shown here will be useful to guide efforts to target BHRF1 in EBV-associated malignancies, which are usually associated with poor clinical outcomes.


Bim Binding (complex) of associated with antagonist and epstein-barr virus
3) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC3009601 Disease Relevance 1.11 Pain Relevance 0.05
In this study, we have confirmed that EBV BHRF1 exerts its pro-survival function by directly inhibiting a sub-set of pro-apoptotic Bcl-2 family proteins Bid, Bim, Puma and Bak, presumably ones most critical for the virus.
Bim Binding (inhibiting) of associated with epstein-barr virus and apoptosis
4) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009601 Disease Relevance 1.30 Pain Relevance 0
It is noteworthy that in some lymphoid cells, the pro-survival action of BHRF1 tracked with its ability to bind Bim [31], which is critical for apoptosis induced by multiple stimuli in this cell type [33] and plays a role in suppressing myc-driven lymphomagenesis [34].


Bim Binding (bind) of associated with apoptosis
5) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009601 Disease Relevance 0.69 Pain Relevance 0

General Comments

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