INT352149

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Ift88, Bcl2l1) cytoplasm (Ift88, Bcl2l1) cell proliferation (Bcl2l1)
cytosol (Bcl2l1) mitochondrion (Bcl2l1) growth (Bcl2l1)
Anatomy Link Frequency
groove 1
Ift88 (Mus musculus)
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 26 78.08 Quite High
Targeted Disruption 3 56.16 Quite High
Epstein-barr Virus 29 54.08 Quite High
B-cell Acute Lymphoblastic Leukemia 1 45.76 Quite Low
Lymphatic System Cancer 9 44.48 Quite Low
Syndrome 1 43.76 Quite Low
Malignant Neoplastic Disease 1 39.20 Quite Low
Disease 4 26.48 Quite Low
Death 7 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since BHRF1 engages BH3 domains using a hydrophobic groove (Fig. 4) in a manner equivalent to that of its mammalian counterparts, conserving key interactions, we asked whether ABT-737, a BH3 mimetic compound known to inhibit Bcl-2, Bcl-xL, and Bcl-w [40], [41], could also target BHRF1.
ABT-737 Negative_regulation (inhibit) of Bcl-xL in groove
1) Confidence 0.00 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009601 Disease Relevance 0.19 Pain Relevance 0

General Comments

This test has worked.

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