INT352186

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.56
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (A4GALT) Golgi apparatus (A4GALT) plasma membrane organization (A4GALT)
Anatomy Link Frequency
plasma 4
urine 2
A4GALT (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 120 99.60 Very High Very High Very High
Neuropathic pain 16 98.04 Very High Very High Very High
imagery 92 5.00 Very Low Very Low Very Low
depression 32 5.00 Very Low Very Low Very Low
fibrosis 28 5.00 Very Low Very Low Very Low
cva 24 5.00 Very Low Very Low Very Low
aspirin 16 5.00 Very Low Very Low Very Low
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
Analgesic 12 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fabry Disease 768 99.76 Very High Very High Very High
Pain 140 99.60 Very High Very High Very High
Neuropathic Pain 28 98.04 Very High Very High Very High
Hypohidrosis 12 85.04 High High
Body Weight 8 82.20 Quite High
Disease 188 75.36 Quite High
Disease Progression 16 68.04 Quite High
Renal Disease 104 54.52 Quite High
Targeted Disruption 8 38.48 Quite Low
Proteinuria 84 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When silenced HK2 cells were reconstituted with agalsidase alfa, they decreased their membranous CD77 expression to levels indistinguishable from those of non-silenced cells.
Negative_regulation (decreased) of Gene_expression (expression) of CD77
1) Confidence 0.20 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 0.42 Pain Relevance 0
In the 3.5-year extension study of one of the pediatric clinical trials, there were sustained, statistically significant improvements in the clinical features of FD, including reduced plasma Gb3 levels, reduced pain severity assessed by the brief pain inventory (BPI) questionnaire, and improved heart rate variability.
Negative_regulation (reduced) of Gene_expression (levels) of Gb3 in plasma associated with pain and fabry disease
2) Confidence 0.14 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 0.78 Pain Relevance 0.41
In two pediatric clinical trials of ERT with agalsidase alfa, including 37 children [342,343], boys demonstrated reductions in plasma Gb3 levels, and both boys and girls reported reductions in neuropathic pain and in the use of neuropathic pain medications.
Negative_regulation (reductions) of Gene_expression (levels) of Gb3 in plasma associated with neuropathic pain
3) Confidence 0.14 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 0.60 Pain Relevance 0.19
Mean urine Gb3 levels were reduced to normal range.
Negative_regulation (reduced) of Gene_expression (levels) of Gb3 in urine
4) Confidence 0.12 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3009617 Disease Relevance 0.77 Pain Relevance 0.46

General Comments

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