INT352196

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.62
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Igkv12-66 (Mus musculus)
Gm10404 (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 12 100.00 Very High Very High Very High
cINOD 24 99.02 Very High Very High Very High
Inflammation 44 98.78 Very High Very High Very High
Antinociceptive 38 97.12 Very High Very High Very High
Thermal hyperalgesia 26 96.88 Very High Very High Very High
Analgesic 16 92.68 High High
IPN 8 85.44 High High
Pain 20 80.72 Quite High
Arthritis 20 78.48 Quite High
Neuropathic pain 2 75.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 44 98.78 Very High Very High Very High
Hyperalgesia 48 96.88 Very High Very High Very High
Sprains And Strains 2 89.12 High High
Nociception 26 87.08 High High
Inflammatory Pain 8 85.44 High High
Pain 20 80.72 Quite High
Arthritis 32 78.48 Quite High
Neuropathic Pain 2 75.96 Quite High
Disease 10 70.80 Quite High
Pressure And Volume Under Development 2 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The administration of a selective inhibitor of COX-1, FR122047 (10 mg/kg intraperitoneally) or a selective inhibitor of COX-2, CAY10404 (10 mg/kg intraperitoneally) to BALB/c did not result in a significant change in reaction latency compared to baseline latency in the hot plate or compared to vehicle treatment (Table 3).
FR122047 Negative_regulation (inhibitor) of CAY10404
1) Confidence 0.00 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009629 Disease Relevance 0.15 Pain Relevance 0.10
In this study the antinociceptive effects of co-administration of minocycline with a non-steroidal anti-inflammatory drug (NSAID), indomethacin, a selective inhibitor of COX-1, FR122047 or a selective COX-2 inhibitor, CAY10404, were evaluated in naïve mice and mice with lipopolysaccharide (LPS)-induced thermal hyperalgesia and monoarthritis.
FR122047 Negative_regulation (inhibitor) of CAY10404 associated with inflammation, thermal hyperalgesia, cinod, cox-2 inhibitor and antinociceptive
2) Confidence 0.00 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009629 Disease Relevance 1.47 Pain Relevance 1.24

General Comments

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