INT352201

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (ALOX5, Cpox) cytoplasm (ALOX5, Cpox) cytosol (ALOX5)
mitochondrion (Cpox) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
ALOX5 (Homo sapiens)
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 19 98.30 Very High Very High Very High
Arthritis 10 89.88 High High
Pain 10 89.20 High High
Inflammation 22 88.84 High High
analgesia 1 81.60 Quite High
rheumatoid arthritis 8 77.52 Quite High
cytokine 6 76.12 Quite High
cINOD 12 62.16 Quite High
Osteoarthritis 2 60.08 Quite High
Thermal hyperalgesia 13 50.00 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 16 89.88 High High
Pain 10 89.20 High High
INFLAMMATION 22 88.84 High High
Rheumatoid Arthritis 8 77.52 Quite High
Disease 5 70.40 Quite High
Knee Osteoarthritis 1 60.08 Quite High
Hyperalgesia 24 50.00 Quite Low
Nociception 13 5.00 Very Low Very Low Very Low
Inflammatory Pain 4 5.00 Very Low Very Low Very Low
Crystal Associated Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other possible reasons for the enhanced antinociceptive activity by coadministering minocycline and indomethacin could have been due to the inhibition of COX enzyme activity by indomethacin and inhibition of 5-lipoxygenase activity by minocycline.
Negative_regulation (inhibition) of 5-lipoxygenase Negative_regulation (inhibition) of COX enzyme associated with antinociceptive
1) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009629 Disease Relevance 0.89 Pain Relevance 0.81

General Comments

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