INT352256

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.32
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (Rgn) nucleus (Rgn) cytoplasm (Rgn)
Anatomy Link Frequency
Nerve 1
Rgn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 7 94.94 High High
Nerve growth factor 5 93.02 High High
antidepressant 46 64.00 Quite High
Somatostatin 2 52.20 Quite High
Hippocampus 9 50.00 Quite Low
fluoxetine 11 35.04 Quite Low
Inflammation 5 13.12 Low Low
depression 13 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
monoamine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 8 97.90 Very High Very High Very High
Cancer 18 95.56 Very High Very High Very High
Necrosis 14 95.32 Very High Very High Very High
Apoptosis 14 92.36 High High
INFLAMMATION 6 13.12 Low Low
Depression 13 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, treatment with phenelzine resulted in up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Fyn proto-oncogene), 14 (Nerve growth factor beta, Midkine, Type 1 tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Leptin receptor, Adrenomedullin, Arrestin beta 1, Syntaxin 1A, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, Growth differentiation factor 15, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of four (Immunoglobulin superfamily member 6, Secreted phosphoprotein 1, Phospholipase A2 activating protein, Tumor necrosis factor receptor superfamily member 6), three (Serum amyloid A 4, Apoptosis facilitator Bcl-2-like protein 14, Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after treatment for one, three and seven days, respectively (Table 1 and 2).
Negative_regulation (regulation) of Regucalcin in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and apoptosis
1) Confidence 0.20 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.32 Pain Relevance 0.15

General Comments

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