INT352256

Context Info Confidence 0.20 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.32 Pain Relevance 0.15

enzyme regulator activity (Rgn) nucleus (Rgn) cytoplasm (Rgn)

Anatomy Link Frequency Nerve 1 Rgn (Rattus norvegicus)

Pain Link Frequency Relevance Heat adenocard 7 94.94 Nerve growth factor 5 93.02 antidepressant 46 64.00 Somatostatin 2 52.20 Hippocampus 9 50.00 fluoxetine 11 35.04 Inflammation 5 13.12 depression 13 5.00 cytokine 12 5.00 monoamine 9 5.00

Disease Link Frequency Relevance Heat Alzheimer's Dementia 8 97.90 Cancer 18 95.56 Necrosis 14 95.32 Apoptosis 14 92.36 INFLAMMATION 6 13.12 Depression 13 5.00 Anxiety Disorder 8 5.00 Neurodegenerative Disease 6 5.00 Sleep Disorders 3 5.00 Injury 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finally, treatment with phenelzine resulted in up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Fyn proto-oncogene), 14 (Nerve growth factor beta, Midkine, Type 1 tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Leptin receptor, Adrenomedullin, Arrestin beta 1, Syntaxin 1A, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, Growth differentiation factor 15, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of four (Immunoglobulin superfamily member 6, Secreted phosphoprotein 1, Phospholipase A2 activating protein, Tumor necrosis factor receptor superfamily member 6), three (Serum amyloid A 4, Apoptosis facilitator Bcl-2-like protein 14, Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after treatment for one, three and seven days, respectively (Table 1 and 2).

Negative_regulation (regulation) of Regucalcin in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and apoptosis

1) Confidence 0.20 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.32 Pain Relevance 0.15

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