INT352261

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.50
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme regulator activity (Rgn) nucleus (Rgn) cytoplasm (Rgn)
Anatomy Link Frequency
Nerve 1
Rgn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 7 100.00 Very High Very High Very High
Nerve growth factor 5 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
Inflammation 5 92.84 High High
fluoxetine 11 70.88 Quite High
antidepressant 46 50.00 Quite Low
Hippocampus 9 50.00 Quite Low
depression 13 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
monoamine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 18 100.00 Very High Very High Very High
Necrosis 14 100.00 Very High Very High Very High
Alzheimer's Dementia 8 100.00 Very High Very High Very High
INFLAMMATION 6 92.84 High High
Apoptosis 14 81.52 Quite High
Depression 13 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with imipramine resulted in significant up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Tumor necrosis factor member 11), 13 (Nerve growth factor beta, tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Neurotrophic tyrosine kinase receptor type 2, Somatostatin receptor 5, Leptin receptor, Arrestin beta 1, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, RAB6A member RAS oncogene family, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of five (Leukocyte cell derived chemotaxin 1, Phospholipase A2 activating protein, Mitogen-activated protein kinase), one (Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after one, three and seven days of treatment, respectively.
Gene_expression (expressed) of Regucalcin in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and somatostatin
1) Confidence 0.28 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.50 Pain Relevance 0.32

General Comments

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