INT352264

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.60
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Degs1) endoplasmic reticulum (Degs1)
Degs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 46 50.00 Quite Low
Hippocampus 9 50.00 Quite Low
Bile 2 38.08 Quite Low
depression 13 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
fluoxetine 11 5.00 Very Low Very Low Very Low
monoamine 9 5.00 Very Low Very Low Very Low
Serotonin 9 5.00 Very Low Very Low Very Low
tricyclic antidepressant 8 5.00 Very Low Very Low Very Low
adenocard 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute-phase Reaction 4 85.52 High High
Gallstones 4 81.68 Quite High
Hepatotoxicity 4 80.64 Quite High
Death 6 77.68 Quite High
Toxicity 14 75.04 Quite High
Aging 45 66.68 Quite High
Disease 10 51.84 Quite High
Hyperplasia 2 38.76 Quite Low
Liver Cell Adenoma 2 30.16 Quite Low
Body Weight 4 5.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, fold change and a Welch t-test were used to select the differentially expressed genes (DEGs) using a fold change threshold of 2.0-fold and a P < 0.05 to indicate significance.
Gene_expression (expressed) of DEGs
1) Confidence 0.46 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 0 Pain Relevance 0
The initial filtering criteria of p < 0.05 for sex or age difference with an absolute fold-change greater than or equal to 1.5 in relative expression at any age was used to define a set of 7,951 differentially expressed features comprising 3,770 unique Entrez Gene IDs or differentially expressed genes (DEGs).
Gene_expression (expressed) of DEGs
2) Confidence 0.21 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
Analysis software Ingenuity Pathway Analysis (IPA) was used to assist in biological interpretation of the expression data from the initial list of 3,770 DEGs with unique EntrezGene IDs.
Gene_expression (expression) of DEGs
3) Confidence 0.21 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.60 Pain Relevance 0

General Comments

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