INT352295

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.08
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (P2RY2, Agtr1a) plasma membrane (P2RY2, Agtr1a) signal transducer activity (P2RY2, Agtr1a)
endosome (Agtr1a) mitochondrion (P2RY2) Golgi apparatus (Agtr1a)
Anatomy Link Frequency
brain 6
P2RY2 (Homo sapiens)
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 6 99.08 Very High Very High Very High
Pyramidal cell 36 96.00 Very High Very High Very High
adenocard 36 92.24 High High
Kinase C 6 88.64 High High
Pain 6 84.00 Quite High
Hippocampus 36 83.40 Quite High
medulla 6 74.44 Quite High
amygdala 6 73.28 Quite High
agonist 6 70.24 Quite High
anesthesia 6 18.08 Low Low
Disease Link Frequency Relevance Heat
Pain 6 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the heteromeric interaction of A1R and P2Y2R in situ in brain is still largely unknown.


P2Y2R Binding (interaction) of A1R in brain
1) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Abstract Doc Link PMC3009664 Disease Relevance 0.08 Pain Relevance 0.25
Co-immunoprecipitation of A1R and P2Y2R from rat brain
P2Y2R Binding (immunoprecipitation) of A1R in brain
2) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.23
The aim of the present study is to determine whether A1R and P2Y2R associate with each other in rat brain by co-immunoprecipitation and looking for receptor complexes via immunogold electron microscopy (IEM).


P2Y2R Binding (associate) of A1R in brain
3) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.08
As in the transfected HEK293T cells, we observed clusters of different-sized gold particles at cytoplasmic membranes in cell bodies, indicating the presence of heteromeric complexes of endogenous A1R and P2Y2R in rat brain (Figure 4E-G).
P2Y2R Binding (complexes) of A1R in brain
4) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.08
The present study provides the first detailed evidence of an interaction between endogenous A1R and P2Y2R in brains using co-immunoprecipitation and IEM.
P2Y2R Binding (interaction) of A1R in brains
5) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.15
Next, we examined whether A1R and P2Y2R are associated with one another in several brain regions using immunoprecipitation with anti-A1R followed by immunoblotting with both A1R and P2Y2R antibodies (Figure 3).
P2Y2R Binding (associated) of A1R in brain
6) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.23

General Comments

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