INT352417

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ccl2, Ccr5) cytoplasm (Ccl2, Ccr5) endosome (Ccr5)
cell-cell signaling (Ccr5) signal transducer activity (Ccr5) extracellular space (Ccl2)
Ccl2 (Rattus norvegicus)
Ccr5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 23 98.08 Very High Very High Very High
Eae 28 78.88 Quite High
Action potential 9 52.76 Quite High
Hyperalgesia 18 50.00 Quite Low
qutenza 2 44.44 Quite Low
agonist 2 44.04 Quite Low
TRP channel 1 43.28 Quite Low
Demyelination 3 9.68 Low Low
chemokine 5 7.40 Low Low
Spinal cord 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 28 78.88 Quite High
Neuropathic Pain 44 74.72 Quite High
Bordatella Infection 1 56.60 Quite High
Hyperalgesia 26 50.00 Quite Low
Nociception 10 46.28 Quite Low
Demyelinating Disease 3 9.68 Low Low
Pain 7 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since rCCL2 can activate both CCR2 and CCR5 [25] we used AZ889 to test if a selective CCR2 antagonist can prevent CCL2-induced calcium signalling in native tissue.
rCCL2 Positive_regulation (activate) of CCR5 associated with antagonist
1) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.26 Pain Relevance 0.14

General Comments

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