INT35242

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 12.53
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MBL2) extracellular region (MBL2)
Anatomy Link Frequency
skin 2
monocytes 1
respiratory 1
MBL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 58 99.56 Very High Very High Very High
Inflammation 169 98.96 Very High Very High Very High
halothane 7 97.28 Very High Very High Very High
Antihistamine 13 93.56 High High
cytokine 66 92.28 High High
chemokine 15 90.80 High High
anesthesia 4 81.68 Quite High
alcohol 1 74.40 Quite High
headache 3 18.48 Low Low
Pain 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 14 99.96 Very High Very High Very High
Lower Respiratory Tract Infection 13 99.90 Very High Very High Very High
Dyspepsia 58 99.56 Very High Very High Very High
Disease 244 99.32 Very High Very High Very High
Skin Infection 117 99.16 Very High Very High Very High
INFLAMMATION 166 98.96 Very High Very High Very High
Eczema 26 98.92 Very High Very High Very High
Infection 207 98.76 Very High Very High Very High
Thrombosis 26 98.68 Very High Very High Very High
Recurrence 26 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other investigators have suggested that diseases such as atopic dermatitis, that present defects in innate immunity, may have a defective MBL response [5].
Negative_regulation (defective) of MBL associated with eczema and disease
1) Confidence 0.48 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 1.03 Pain Relevance 0.24
Similarly, the ability of purified monocytes to inhibit MBL-2 tumor cell growth was unchanged.
Negative_regulation (inhibit) of MBL-2 in monocytes associated with cancer
2) Confidence 0.48 Published 1987 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 3125239 Disease Relevance 0.10 Pain Relevance 0.51
MBL functional pathway test was impaired (Table 2).
Negative_regulation (impaired) of MBL
3) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 1.11 Pain Relevance 0
It appears that MBL deficiency may contribute to recurrent skin infections and to certain forms of inflammatory skin disease.
Negative_regulation (deficiency) of MBL in skin associated with skin infection, inflammation and skin diseases
4) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.90 Pain Relevance 0.10
In the specific case of BD, there are large numbers of PMNs located within mucocutaneous lesions, and MBL deficiency contributes to impaired clearance of these cells after they undergo apoptosis, precipitating the immune response described [37].
Negative_regulation (deficiency) of MBL associated with apoptosis and disease
5) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.92 Pain Relevance 0.13
This might suggest that these findings are coincidental and that MBL deficiency may have no relationship to the infections experienced by the reported group of patients.
Negative_regulation (deficiency) of MBL associated with infection
6) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.77 Pain Relevance 0.04
Hence, innate immunity would be essential in limiting invasion and an exaggerated immune response, with MBL deficiency representing a susceptibility and severity factor in BD [37].
Negative_regulation (deficiency) of MBL associated with disease
7) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.90 Pain Relevance 0.04
The major limitation in our study is the small number of cases, the lack of appropriate controls and the high frequency of MBL deficiency in the population.
Negative_regulation (deficiency) of MBL
8) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.76 Pain Relevance 0.04
The role of MBL deficiency in recurrent fungal folliculitis is not entirely clear, but it is likely that fungal mannan may be able to activate the complement cascade that then leads to activation of a phagocytic and cellular immune response.
Negative_regulation (deficiency) of MBL associated with skin infection
9) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.67 Pain Relevance 0.06
Now, while MBL deficiency has been shown to predispose to arterial thrombosis in patients with autoimmune disorders, no increased risk for development of venous thrombosis was demonstrated [43].
Negative_regulation (deficiency) of MBL associated with autoimmune disease, deep vein thrombosis and thrombosis
10) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.83 Pain Relevance 0.06
It appears that MBL deficiency may contribute to recurrent skin infections and to certain forms of inflammatory skin disease.
Negative_regulation (deficiency) of MBL in skin associated with skin infection, inflammation and skin diseases
11) Confidence 0.41 Published 2010 Journal Clin Mol Allergy Section Abstract Doc Link PMC2856528 Disease Relevance 1.41 Pain Relevance 0.09
The association between recurrent upper respiratory infections and MBL deficiency has been grounds for debate by a number of studies [13-16].
Negative_regulation (deficiency) of MBL in respiratory associated with lower respiratory tract infection
12) Confidence 0.36 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.48 Pain Relevance 0.05
There are seven MBL2 haplotypes, 4 of which are associated with decreased MBL levels (LYPB, LYQC, HYPD, and LXPA), the other 3 (HYPA, LYPA, and LYQA) producing normal levels [9].
Negative_regulation (decreased) of MBL
13) Confidence 0.36 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0 Pain Relevance 0
Further work-up yielded a low level of MBL at < 50 ng/ml (reference: >100 ng/ml), as well as an impaired MBL pathway functional test using the C4b deposition assay.
Negative_regulation (level) of MBL
14) Confidence 0.35 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.48 Pain Relevance 0
To further evaluate the effect of TLR2 and MBL2 polymorphisms on the susceptibility of FD, we investigated the prevalence of both TLR2 and MBL genotypes in H. pylori positive and negative subjects respectively (TableĀ 3).
Spec (investigated) Negative_regulation (prevalence) of MBL associated with nud
15) Confidence 0.17 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 1.01 Pain Relevance 0.34
Four C1-INH-deficient and four healthy persons were found to be MBL deficient (MBL serum concentration below 100 ng/ml).
Negative_regulation (deficient) of MBL
16) Confidence 0.06 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734250 Disease Relevance 0.28 Pain Relevance 0
Deficiencies of terminal complement component, properdin, factor D, and mannan-binding lectin (MBL) have been associated with increased susceptibility to meningo-coccal infection (Pollard and Frasch 2001).
Negative_regulation (Deficiencies) of mannan-binding lectin associated with infection
17) Confidence 0.03 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621387 Disease Relevance 0.90 Pain Relevance 0.04

General Comments

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