INT352456

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.31
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Dusp1, Mapk14) nucleoplasm (Dusp1) mitochondrion (Mapk14)
cell morphogenesis (Mapk14) response to stress (Mapk14) cytoplasm (Mapk14)
Anatomy Link Frequency
nerve 1
Dusp1 (Rattus norvegicus)
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 12 99.08 Very High Very High Very High
Inflammatory response 6 90.76 High High
Pain 12 87.72 High High
Glutamate receptor 2 85.52 High High
fifth nerve 2 84.88 Quite High
cytokine 10 83.68 Quite High
central sensitization 28 83.52 Quite High
Inflammation 28 82.32 Quite High
Calcitonin gene-related peptide 42 81.68 Quite High
Lasting pain 8 76.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 46 99.08 Very High Very High Very High
Nervous System Injury 2 98.12 Very High Very High Very High
Pain 20 87.72 High High
Cognitive Disorder 4 82.28 Quite High
Injury 2 77.44 Quite High
Nociception 28 72.16 Quite High
Temporomandibular Joint Disorders 18 60.88 Quite High
Ganglion Cysts 12 50.00 Quite Low
Chronic Disease 6 48.40 Quite Low
Disease 4 26.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, MKP-1 is reported to preferentially suppress active, phosphorylated p38 levels in response to inflammatory stimuli or nerve injury [29].
MKP-1 Negative_regulation (suppress) of p38 in nerve associated with nervous system injury and inflammatory stimuli
1) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 1.09 Pain Relevance 0.91
MKP-1 is reported to dephosphorylate, and therefore, inactivate several MAP kinases including p38, JNK, and ERK, in a concentration dependent manner [33].
MKP-1 Negative_regulation (inactivate) of p38
2) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.23 Pain Relevance 0.12

General Comments

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