INT35248

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Context Info
Confidence 0.51
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 2.38
Pain Relevance 5.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi) carbohydrate metabolic process (Gpi) cytoplasm (Gpi)
cytosol (Gpi) extracellular space (Gpi) extracellular region (Gpi)
Anatomy Link Frequency
neuronal 2
synapses 2
entopeduncular nucleus 1
GPI 1
liver 1
Gpi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 822 100.00 Very High Very High Very High
midbrain 30 100.00 Very High Very High Very High
Opioid 22 100.00 Very High Very High Very High
addiction 21 100.00 Very High Very High Very High
Glutamate 62 99.90 Very High Very High Very High
agonist 230 99.66 Very High Very High Very High
gABA 207 99.62 Very High Very High Very High
Thalamus 80 99.36 Very High Very High Very High
bradykinin 1 97.52 Very High Very High Very High
Dorsal horn 1 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 239 99.16 Very High Very High Very High
Sleep Disorders 86 98.00 Very High Very High Very High
Liver Cancer 4 97.32 Very High Very High Very High
Cancer 7 96.66 Very High Very High Very High
Catalepsy 7 88.72 High High
Targeted Disruption 30 87.92 High High
Parkinson's Disease 168 87.80 High High
Urological Neuroanatomy 14 86.96 High High
Movement Disorders 14 81.76 Quite High
Body Weight 9 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plocamadiene A (1 micrograms/mL) produced a slow onset, sustained contraction of the GPI.
Gene_expression (produced) of GPI in GPI
1) Confidence 0.51 Published 1993 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 7683592 Disease Relevance 0 Pain Relevance 0.18
Collaterals of the GPi/SNr projection to the ventral thalamus reach the intralaminar thalamic centromedian and parafascicular nuclei (CM/PF), as well as brain stem targets such as the pedunculopontine nucleus, and the reticular formation (Smith et al., 2009).


Gene_expression (projection) of GPi in nucleus associated with thalamus
2) Confidence 0.28 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.09 Pain Relevance 0.41
These D2LR-preferring agents may not only act in the striatum, but also at the level of the GPe or its afferents, and perhaps at glutamatergic synapses in GPi and SNr (see above).
Gene_expression (level) of GPi in synapses
3) Confidence 0.28 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.31 Pain Relevance 0.28
In addition, the primate GPi receives its own diffusely arborizing dopaminergic input (Parent and Smith, 1987; Lavoie et al., 1989; Parent et al., 1989; Hedreen, 1999), as demonstrated through the detection of dopamine in GPi (Pifl et al., 1990; Hornykiewicz, 1998), by the presence of DAT in ligand binding studies, and through immunohistochemical investigations on human postmortem tissue (Marcusson and Eriksson, 1988; Ciliax et al., 1999; Porritt et al., 2005), monkey (Gnanalingham et al., 1995) GPi and in the rodent entopeduncular nucleus, the rat homologue to the monkey GPi (Ciliax et al., 1995; Coulter et al., 1995).
Gene_expression (receives) of GPi in entopeduncular nucleus associated with dopamine
4) Confidence 0.25 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.17 Pain Relevance 0.28
Using electron microscopy, we recently found that D2-receptors in the monkey GPi are almost exclusively presynaptic, with some receptors at presumably glutamatergic (i.e., forming asymmetric synapses) terminals (unpublished observations).
Gene_expression (presynaptic) of GPi in synapses
5) Confidence 0.25 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.09 Pain Relevance 0.16
We found that microinjections of a D1LR agonist into the monkey GPi reduces GPi firing rates, and increases neuronal burst discharges and oscillatory firing in the 3–15 Hz range of frequencies.
Gene_expression (reduces) of GPi in neuronal associated with agonist
6) Confidence 0.25 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.08 Pain Relevance 0.30
Studies in rats and monkeys have documented D4-receptor protein in the GPi (Mrzljak et al., 1996; Rivera et al., 2003).
Gene_expression (documented) of GPi
7) Confidence 0.25 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.08 Pain Relevance 0.12
We found that microinjections of a D1LR agonist into the monkey GPi reduces GPi firing rates, and increases neuronal burst discharges and oscillatory firing in the 3–15 Hz range of frequencies.
Gene_expression (reduces) of GPi in neuronal associated with agonist
8) Confidence 0.25 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.08 Pain Relevance 0.30
PHI- and VIP-like immunoreactivity were expressed in parallel in increasing amounts in the superficial laminae of the dorsal horn after transection of the sciatic nerve [G.
Gene_expression (expressed) of PHI in sciatic nerve associated with dorsal horn and sciatic nerve
9) Confidence 0.24 Published 1987 Journal Neuroscience Section Abstract Doc Link 3125490 Disease Relevance 0 Pain Relevance 0.30
BACKGROUND AND AIMS: We have developed a novel tumor-ablation device for liver tumors utilizing heat energy induced by magnesium ferrite (MgFe(2)O(4)) particles under an alternating magnetic field (AMF) produced by electric currents.
Gene_expression (produced) of AMF in liver associated with liver cancer and cancer
10) Confidence 0.17 Published 2008 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 18444992 Disease Relevance 0.44 Pain Relevance 0.09
On the other hand, cFos expression in the ventral striatum (i.e., the nucleus of the accumbens), GPi and SNr was considerably lower during both wakefulness and sleep but slightly higher in the GPi and SNr during wakefulness (of both types) than during sleep.
Gene_expression (expression) of GPi in striatum
11) Confidence 0.14 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2996256 Disease Relevance 0.23 Pain Relevance 0.05
It is likely that both GABA and glutamate are present in the same neurons in the GPi, but it has never been confirmed.
Gene_expression (present) of GPi in GPi associated with glutamate and gaba
12) Confidence 0.14 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2996256 Disease Relevance 0.05 Pain Relevance 0.99
Recently, it has been demonstrated that catecolaminergic system is involved in the control of the expression of opioid acute dependence in GPI [32, 47].
Gene_expression (expression) of GPI associated with addiction and opioid
13) Confidence 0.07 Published 2009 Journal The Open Biochemistry Journal Section Body Doc Link PMC2811858 Disease Relevance 0 Pain Relevance 1.19
The major source of dopamine in the BG is the midbrain dopaminergic neurons, particularly the SNc (A9 group), and these neurons primarily target the striatum, GPe and GPi.
Gene_expression (source) of GPi in neurons associated with dopamine and midbrain
14) Confidence 0.06 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2996256 Disease Relevance 0.71 Pain Relevance 0.52
In aortas of Wistar rats, the transcripts of COX-2 and PGI-S were overexpressed as compared to COX-1.
Gene_expression (overexpressed) of PGI-S in aortas
15) Confidence 0.04 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592556 Disease Relevance 0.05 Pain Relevance 0.27
PHI is found in abundance in the SCN and is co-localized [162,163].
Gene_expression (found) of PHI
16) Confidence 0.02 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.06

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