INT352519

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Context Info
Confidence 0.07
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.97
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Slc2a4) transport (Slc2a4) small molecule metabolic process (INS)
carbohydrate metabolic process (INS) transmembrane transport (Slc2a4) cytoplasm (Slc2a4)
Anatomy Link Frequency
skeletal muscle 2
INS (Homo sapiens)
Slc2a4 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 16 54.40 Quite High
Inflammation 3 15.36 Low Low
cytokine 2 14.32 Low Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 19 94.72 High High
Cancer 4 93.12 High High
Necrosis 4 92.64 High High
Insulin Resistance 1 80.28 Quite High
Parkinson's Disease 2 75.04 Quite High
Frailty 11 62.72 Quite High
Obesity 17 59.12 Quite High
Impaired Glucose Tolerance 29 54.40 Quite High
Apoptosis 4 52.00 Quite High
Diabetes Mellitus 43 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serine kinases impede insulin signaling by reducing IRS phosphorylation [64, 65, 72] which leads to a decline in insulin-stimulated GLUT4 translocation and impaired skeletal muscle glucose uptake [64, 65].

3.4.

insulin Positive_regulation (stimulated) of Localization (translocation) of GLUT4 in skeletal muscle
1) Confidence 0.07 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.97 Pain Relevance 0.03

General Comments

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