INT35254

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Context Info
Confidence 0.48
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 11.42
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINB1) cytoplasm (SERPINB1)
Anatomy Link Frequency
platelet 2
CSF 1
Striatum 1
respiratory tract 1
hypothalamus 1
SERPINB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 15 100.00 Very High Very High Very High
Serotonin 9 100.00 Very High Very High Very High
Analgesic 1 100.00 Very High Very High Very High
Inflammation 68 98.32 Very High Very High Very High
Multiple sclerosis 71 98.12 Very High Very High Very High
rheumatoid arthritis 33 97.50 Very High Very High Very High
cytokine 28 95.96 Very High Very High Very High
Pain 1 92.76 High High
Migraine 2 91.92 High High
COX-2 inhibitor 4 90.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 81 99.84 Very High Very High Very High
Disease 225 98.36 Very High Very High Very High
Multiple Sclerosis 69 98.12 Very High Very High Very High
Rheumatoid Arthritis 34 97.50 Very High Very High Very High
Dementia 17 96.68 Very High Very High Very High
Meningitis 114 95.24 Very High Very High Very High
Atherosclerosis 4 95.24 Very High Very High Very High
Cognitive Disorder 56 94.52 High High
Infection 22 93.32 High High
Pain 1 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The morphological alterations, however, induced by nicotine, are less pronounced and therefore, other substances and pathophysiologic mechanisms, such as carcinogen action or cigarette smoke-induced reduction of anti-protease activity, are likely to aggravate pancreatic damage upon cigarette smoke inhalation.
Negative_regulation (reduction) of anti-protease
1) Confidence 0.48 Published 2008 Journal Langenbecks Arch Surg Section Body Doc Link 18193450 Disease Relevance 0 Pain Relevance 0
Several factors may be involved and these probably interact: decreased access of cortisol to the inflammatory site secondary to the reduction in circulating CBG; modulation of local cortisol level by a reduction in the cleavage of CBG–cortisol complex (antielastase activity); reduction in the number and affinity of glucocorticoid receptors, shown on lymphocytes treated with different cytokines; and a rise in the conversion of cortisol in inactive cortisone by increased activity of the 11 ?
Negative_regulation (reduction) of antielastase in lymphocytes associated with inflammation and cytokine
2) Confidence 0.42 Published 2004 Journal Crit Care Section Body Doc Link PMC420022 Disease Relevance 0.54 Pain Relevance 0.17
Serpin B1 is a leukocyte elastase inhibitor and regulates the activity of the neutrophil proteases elastase, cathepsin G and proteinase-3.
Negative_regulation (inhibitor) of Serpin B1 in neutrophil
3) Confidence 0.10 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 1.03 Pain Relevance 0.23
Their anti-inflammatory properties might provoke anti-atherogenic effects but on the other hand, selective inhibition of anti-thrombotic prostacyclin and COX-2 independent effects might promote the risk of increased prothrombotic activity.
Negative_regulation (inhibition) of anti-thrombotic prostacyclin associated with inflammation
4) Confidence 0.06 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15194006 Disease Relevance 1.02 Pain Relevance 0.53
It was found that tenidap, in contrast to several nonsteroidal anti-inflammatory drugs, inhibits anti-CD3 or IL-2 driven proliferative responses of cloned human T-cells.
Negative_regulation (inhibits) of anti-CD3 in T-cells associated with inflammation and cinod
5) Confidence 0.06 Published 1995 Journal Scand. J. Immunol. Section Abstract Doc Link 8552993 Disease Relevance 0.60 Pain Relevance 0.51
Anti-cyclo-oxygenase analgesics block PGE2 production, and allow cytotoxic lymphocytes to attack and kill their target cells, i.e. the virus-affected cells of the respiratory tract.
Negative_regulation (block) of Anti-cyclo-oxygenase in respiratory tract associated with analgesic
6) Confidence 0.03 Published 1988 Journal Clin. Allergy Section Abstract Doc Link 3127083 Disease Relevance 0.64 Pain Relevance 0.18
Furthermore, no data are currently available in RA patients regarding the long-term effect of anti-TNF treatment on other autoantibodies, including rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies, levels of which are related to the severity of the rheumatoid process [17-20] and could be reduced by an effective antirheumatic therapy [21].
Negative_regulation (reduced) of anti-cyclic citrullinated peptide associated with rheumatoid arthritis
7) Confidence 0.02 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416448 Disease Relevance 1.06 Pain Relevance 0.47
This suggests the existence of in vivo sites of action for the synergistic inhibitory activity of NSAID and anti-histamine/anti-serotonin drugs on bronchoconstriction and on platelet secretion.
Negative_regulation (inhibitory) of anti-serotonin in platelet associated with cinod and serotonin
8) Confidence 0.01 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7128682 Disease Relevance 0.35 Pain Relevance 0.59
This suggests the existence of in vivo sites of action for the synergistic inhibitory activity of NSAID and anti-histamine/anti-serotonin drugs on bronchoconstriction and on platelet secretion.
Negative_regulation (inhibitory) of anti-histamine in platelet associated with cinod and serotonin
9) Confidence 0.01 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7128682 Disease Relevance 0.35 Pain Relevance 0.59
In the hypothalamus, NE alone or in presence of EE2 had no significant effect on beta-EI, but 10X dose of NE+ EE2 caused 50 and 76% decrease in beta-EI in acute and chronic study.
Negative_regulation (decrease) of beta-EI in hypothalamus
10) Confidence 0.01 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319907 Disease Relevance 0 Pain Relevance 0.18
Striatum was the only tissue where NE alone caused a decrease of 82% in beta-EI when given acutely and 52% when given chronically.
Negative_regulation (decrease) of beta-EI in Striatum
11) Confidence 0.01 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319907 Disease Relevance 0 Pain Relevance 0.29
EE2 had some protective effect on this decrease since when given together (NE+EE2) the decrease in beta-EI was 21% in acute and 43% in chronic study.
Negative_regulation (decrease) of beta-EI
12) Confidence 0.01 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319907 Disease Relevance 0 Pain Relevance 0.37
A decrease in the levels of anti-dsDNA, anti-ribosomal P, anti-cardiolipin, anti-?
Negative_regulation (decrease) of anti-ribosomal P
13) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556096 Disease Relevance 0.77 Pain Relevance 0
A significant decrease in the levels of anti-dsDNA and anti-ribosomal P antibodies was observed at six months.
Negative_regulation (decrease) of anti-ribosomal P
14) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556096 Disease Relevance 0.41 Pain Relevance 0
Nevertheless, among the patients with central NPSLE who tested positive at baseline, a decrease in the levels of anti-dsDNA, anti-ribosomal P, and anti-NMDAR antibodies was observed.
Negative_regulation (decrease) of anti-ribosomal P
15) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556096 Disease Relevance 0.74 Pain Relevance 0.20
Among the patients with central NPSLE who tested positive at baseline, a decrease in the levels of anti-dsDNA, anti-ribosomal P, and anti-NMDAR antibodies was observed in 14 out of 17, 9 out of 10, and 7 out of 9 patients, respectively.
Negative_regulation (decrease) of anti-ribosomal P
16) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556096 Disease Relevance 0.56 Pain Relevance 0
A decrease in the levels of anti-dsDNA, anti-ribosomal P, anti-cardiolipin, anti-?
Negative_regulation (decrease) of anti-cardiolipin
17) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556096 Disease Relevance 0.77 Pain Relevance 0
A plasma and Cerebrospinal fluid (CSF) biomarker study evaluated the long-term ChEI inhibitory effect of rivastigmine in eleven patients with AD treated for 12 months.
Negative_regulation (effect) of ChEI in CSF associated with disease
18) Confidence 0.00 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 0.92 Pain Relevance 0.20
The prevalence of anti-AnnV, anti-PT, anti-Cprot and anti-Sprot was 19%, 10.4%, 4.4% and 8.1%, respectively.
Negative_regulation (prevalence) of anti-PT
19) Confidence 0.00 Published 2008 Journal Immunol. Invest. Section Abstract Doc Link 18569076 Disease Relevance 0.41 Pain Relevance 0.09
The prevalence of anti-AnnV, anti-PT, anti-Cprot and anti-Sprot was 19%, 10.4%, 4.4% and 8.1%, respectively.
Negative_regulation (prevalence) of anti-Sprot
20) Confidence 0.00 Published 2008 Journal Immunol. Invest. Section Abstract Doc Link 18569076 Disease Relevance 0.41 Pain Relevance 0.09

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