INT352555

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Context Info
Confidence 0.01
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DKK1, Wnt2) cell-cell signaling (Wnt2) cytoplasm (Wnt2)
signal transducer activity (DKK1) extracellular space (DKK1) signal transduction (DKK1)
DKK1 (Homo sapiens)
Wnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 99.64 Very High Very High Very High
fibrosis 110 98.24 Very High Very High Very High
tolerance 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 110 98.24 Very High Very High Very High
Hypercalcemia 11 89.88 High High
Targeted Disruption 1 62.72 Quite High
Osteoporosis 14 6.36 Low Low
Bone Cancer 25 5.00 Very Low Very Low Very Low
Pulmonary Disease 8 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Exocrine Pancreatic Insufficiency 5 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-Dkk1 AntibodyDickoppf1 (DKK1) is a naturally occurring Wnt pathway antagonist which works by preventing the interaction between two key Wnt pathway coreceptors, LRP5/6 and the frizzled Wnt pathway receptor, which results in inhibition of Wnt signal transduction and impaired bone formation [105].
DKK1 Positive_regulation (occurring) of Wnt associated with antagonist
1) Confidence 0.01 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.25 Pain Relevance 0.10

General Comments

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