INT352609

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Context Info
Confidence 0.58
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdgfra) nucleus (Pdgfra) extracellular matrix organization (Pdgfra)
kinase activity (Pdgfra) cytoplasm (Pdgfra)
Anatomy Link Frequency
brain 2
Pdgfra (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 10 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 90 93.44 High High
Cancer 144 88.36 High High
Brain Tumor 120 81.56 Quite High
Targeted Disruption 18 74.56 Quite High
Glioblastoma 36 57.52 Quite High
Oligodendroglioma 10 40.08 Quite Low
Apoptosis 52 5.00 Very Low Very Low Very Low
Stress 16 5.00 Very Low Very Low Very Low
Aging 14 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-positive precursors in the brain and/or for upregulation of Pdgfra expression at the promoter level.
Positive_regulation (upregulation) of Gene_expression (expression) of Pdgfra in brain
1) Confidence 0.58 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.45 Pain Relevance 0
The model was created to mimic human secondary GBs characterized by combined PDGFRA overexpression/amplification and TP53 deletion/mutation, and results did prove that this combination is instrumental in generating GBs.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PDGFRA
2) Confidence 0.36 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.74 Pain Relevance 0

General Comments

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