INT352658

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PRKDC) protein modification process (PRKDC) nucleus (PRKDC)
enzyme binding (PRKDC) DNA binding (PRKDC) transcription factor binding (PRKDC)
Anatomy Link Frequency
neurons 1
PRKDC (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 9 25.36 Quite Low
amygdala 58 5.00 Very Low Very Low Very Low
nMDA receptor 25 5.00 Very Low Very Low Very Low
Glutamate 21 5.00 Very Low Very Low Very Low
long-term potentiation 14 5.00 Very Low Very Low Very Low
Pyramidal cell 8 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
anticonvulsant 5 5.00 Very Low Very Low Very Low
Glutamate receptor 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autism 314 91.48 High High
Stress 9 52.84 Quite High
Anxiety Disorder 52 52.12 Quite High
Cognitive Disorder 43 46.08 Quite Low
Aggression 1 26.64 Quite Low
Adverse Drug Reaction 1 16.52 Low Low
Epilepsy 3 16.16 Low Low
Syndrome 21 11.28 Low Low
Intellectual Impairment 24 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The molecular, synaptic, and cellular causes may differ in different regions.The loss of inhibition and hence hyper-reactivity also in sub-cortical regions where inhibitory neurons are more prominent such as in the cerebellum.System level:The variance, as opposed to the mean, of the pixel intensities in fMRI measures should be higher in autistic subjects with the upper and lower intensities being greater than in neurotypical subjects.
Negative_regulation (loss) of hyper-reactivity in neurons associated with autism
1) Confidence 0.01 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.33 Pain Relevance 0

General Comments

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