INT352684

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.22 Pain Relevance 0

mitochondrion (RILP) lysosome (RILP)

RILP (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 2 30.96 chemokine 2 25.32 Pain 4 5.00 palliative 1 5.00 peripheral neuropathy 1 5.00 cytokine 1 5.00 fibrosis 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Disease 25 92.44 Gauchers Disease 86 70.68 Conjunctivitis 1 37.20 Neurologic Manifestations 8 5.00 Infection 8 5.00 Rare Diseases 7 5.00 Aseptic Necrosis Of Bone 5 5.00 Congenital Anomalies 4 5.00 Anaemia 3 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the case of lysosomal enzymes, the chaperone concept involves the binding of the agent to the active site of the mutant lysosomal protein, thus stabilizing it for delivery to its normal site of action in the acidic environment of the organelle.

Regulation (involves) of mutant lysosomal protein Binding (binding) of

1) Confidence 0.01 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC3010821 Disease Relevance 0.22 Pain Relevance 0

General Comments

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