INT35269

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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 38
Total Number 40
Disease Relevance 14.68
Pain Relevance 9.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
anterior 2
fibroblasts 2
neurons 2
chondrocytes 1
cleavage 1
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 9 100.00 Very High Very High Very High
Neurotransmitter 1 100.00 Very High Very High Very High
Glutamate receptor 1 99.96 Very High Very High Very High
Botox 2 99.90 Very High Very High Very High
reflex sympathetic dystrophy 4 99.84 Very High Very High Very High
local anesthetic 1 99.64 Very High Very High Very High
Serotonin 1 99.58 Very High Very High Very High
metalloproteinase 2 99.44 Very High Very High Very High
Morphine 13 99.00 Very High Very High Very High
Pain 250 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 19 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 5 100.00 Very High Very High Very High
Usher Syndrome 3 100.00 Very High Very High Very High
Coronary Artery Disease 6 99.84 Very High Very High Very High
Hypercalcemia 4 98.76 Very High Very High Very High
Pressure And Volume Under Development 7 98.64 Very High Very High Very High
Pain 246 98.50 Very High Very High Very High
Stress Incontinence 1 98.28 Very High Very High Very High
Injury 5 98.24 Very High Very High Very High
Urological Neuroanatomy 6 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After diagnostic coronary angiography, femoral artery endothelial and smooth muscle function were assessed by infusing acetylcholine (ACh) and nitroglycerin (GTN), and tissue-type plasminogen activator (t-PA) release across the femoral circulation was measured as the difference between arterial and venous concentrations before and after ACh and GTN stimulation.
Localization (release) of type in femoral artery
1) Confidence 0.78 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16014611 Disease Relevance 1.06 Pain Relevance 0.12
Challenge with morphine for 24 h (1 nM to 1 microM) barely affected cell proliferation, while the secretion of urokinase type plasminogen activator (a protease involved in invasion/metastasis) was markedly augmented by a concentration of 0.1 microM.
Localization (secretion) of type associated with metastasis and morphine
2) Confidence 0.78 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 17680363 Disease Relevance 0.63 Pain Relevance 0.33
Frequent colocalization of mu opioid and NMDA-type glutamate receptors at postsynaptic sites in periaqueductal gray neurons.
Localization (colocalization) of type in neurons associated with glutamate receptor, central grey and opioid
3) Confidence 0.78 Published 1999 Journal J. Comp. Neurol. Section Title Doc Link 10340504 Disease Relevance 0.54 Pain Relevance 1.29
Hyaline articular cartilage is exclusively composed of chondrocytes that produce primarily type II collagen, whereas the TMJ disc and the knee meniscus have a mixed cell population of fibroblasts and cells similar to chondrocytes, which predominantly secrete type I collagen.
Localization (secrete) of type in chondrocytes associated with snapping jaw
4) Confidence 0.78 Published 2004 Journal Ann Biomed Eng Section Abstract Doc Link 14964717 Disease Relevance 0.62 Pain Relevance 0.23
In situ hybridization histochemistry and immunocytochemistry were used to study localization and activity-dependent regulation of alpha, beta, gamma, and delta isoforms of type II calcium/calmodulin-dependent protein kinase (CaMKII) and their mRNAs in areas 17 and 18 of normal and monocularly deprived adult macaques.
Localization (localization) of type
5) Confidence 0.78 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482799 Disease Relevance 0 Pain Relevance 0.07
There were 2 cases of type 1a, 9 type 2a, 15 type 2b, 7 type 2c, 10 type 3a and 7 type 3b.
Localization (cases) of type
6) Confidence 0.73 Published 2009 Journal Hip Int Section Abstract Doc Link 19462367 Disease Relevance 0.12 Pain Relevance 0.05
OBJECTIVE: To investigate whether botulinum toxin type A (BOTOX) injected into the levator ani muscles of women with objective pelvic floor muscle spasm decreases pain symptoms and improves quality of life.
Localization (injected) of type in muscles associated with pain, stress incontinence, muscular spasm and botox
7) Confidence 0.73 Published 2004 Journal Aust N Z J Obstet Gynaecol Section Abstract Doc Link 15089868 Disease Relevance 0.44 Pain Relevance 0.26
Serotonin 5-hydroxytryptamine type 3 receptors (5HT3R) are Ca2+-permeant, non-selective cation channels that have been localized to presynaptic terminals and demonstrated to modulate neurotransmitter release.
Localization (release) of type associated with neurotransmitter and serotonin
8) Confidence 0.73 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541891 Disease Relevance 0 Pain Relevance 0.40
[Quantitative determination of tissue-type plasminogen activator in varicose soleus veins].
Localization (determination) of type in soleus
9) Confidence 0.73 Published 1987 Journal Phlebologie Section Title Doc Link 3128802 Disease Relevance 0.48 Pain Relevance 0.08
We have shown that nasal ciliated epithelium, which can be easily biopsied under local anesthetic, provides a good source of RNA transcripts from eight of the nine known genes that cause Usher syndrome, namely, MYO7A, USH1C, CDH23, PCDH15, USH1G for Usher type 1, and USH2A, GPR98, WHRN for Usher type 2.
Localization (source) of type in nasal associated with usher syndrome and local anesthetic
10) Confidence 0.73 Published 2010 Journal Hum. Mutat. Section Abstract Doc Link 20513143 Disease Relevance 0.17 Pain Relevance 0.10
Towards an understanding of and explanation for the clinical presentation of CRPS type 1.
Localization (presentation) of type associated with complex regional pain syndromes
11) Confidence 0.73 Published 2008 Journal Rheumatology (Oxford) Section Title Doc Link 18625661 Disease Relevance 0.70 Pain Relevance 0.59
The visual analogue scale (VAS) pain score, Roland Morris Disability Questionnaire (RDQ), Short Form-36 (SF-36) questionnaire, BMD and N-terminal telopeptide of type I collagen (NTx; a marker for bone resorption) were examined before and after treatment.
Spec (examined) Localization (telopeptide) of type associated with visual analogue scale, pain score and hypercalcemia
12) Confidence 0.73 Published 2010 Journal J Clin Neurosci Section Abstract Doc Link 20044258 Disease Relevance 0.87 Pain Relevance 0.65
Urine and serum samples were assessed for levels of the following biomarkers: urinary biomarkers C-telopeptide of type II collagen (uCTX-II), type II and types I and II collagen cleavage neoepitopes (uC2C and uC1,2C, respectively), and N-telopeptide of type I collagen, and serum biomarkers sC1,2C, sC2C, C-propeptide of type II procollagen (sCPII), chondroitin sulfate 846 epitope, cartilage oligomeric matrix protein, and hyaluronic acid.
Localization (telopeptide) of type in cartilage
13) Confidence 0.73 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19404937 Disease Relevance 0.15 Pain Relevance 0
There were 2 cases of type 1a, 9 type 2a, 15 type 2b, 7 type 2c, 10 type 3a and 7 type 3b.
Localization (cases) of type
14) Confidence 0.73 Published 2009 Journal Hip Int Section Abstract Doc Link 19462367 Disease Relevance 0.12 Pain Relevance 0.05
There were 2 cases of type 1a, 9 type 2a, 15 type 2b, 7 type 2c, 10 type 3a and 7 type 3b.
Localization (cases) of type
15) Confidence 0.73 Published 2009 Journal Hip Int Section Abstract Doc Link 19462367 Disease Relevance 0.07 Pain Relevance 0
There were 2 cases of type 1a, 9 type 2a, 15 type 2b, 7 type 2c, 10 type 3a and 7 type 3b.
Localization (cases) of type
16) Confidence 0.73 Published 2009 Journal Hip Int Section Abstract Doc Link 19462367 Disease Relevance 0.12 Pain Relevance 0.05
There were 2 cases of type 1a, 9 type 2a, 15 type 2b, 7 type 2c, 10 type 3a and 7 type 3b.
Localization (cases) of type
17) Confidence 0.73 Published 2009 Journal Hip Int Section Abstract Doc Link 19462367 Disease Relevance 0.12 Pain Relevance 0.05
There were 2 cases of type 1a, 9 type 2a, 15 type 2b, 7 type 2c, 10 type 3a and 7 type 3b.
Localization (cases) of type
18) Confidence 0.73 Published 2009 Journal Hip Int Section Abstract Doc Link 19462367 Disease Relevance 0.06 Pain Relevance 0
Proteinase-activated receptor (PAR) type 2 (PAR-2) has been shown to mediate ion secretion in cultured epithelial cells and rat jejunum.
Localization (secretion) of type in jejunum
19) Confidence 0.73 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11804840 Disease Relevance 0.28 Pain Relevance 0.14
Enhancement of type II adenylyl cyclase responses by the co-expression of alpha subunits reflects a functional coupling between alpha subunits and the mu-opioid receptor, because such potentiations were not observed with the constitutively activated alpha subunit mutants.
Localization (responses) of type associated with opioid receptor
20) Confidence 0.73 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595566 Disease Relevance 0.25 Pain Relevance 0.65

General Comments

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