INT352754

Context Info Confidence 0.13 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.37 Pain Relevance 0.04

plasma membrane (Prkd1) nucleus (Prkd1) intracellular (Prkd1) kinase activity (Prkd1) cytoplasm (Prkd1)

Anatomy Link Frequency neutrophils 2 Sms (Mus musculus) Prkd1 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 11 89.80 ketamine 2 5.00 metalloproteinase 1 5.00 cytokine 1 5.00 Cholecystokinin 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Infection 33 98.76 Fungal Infection 19 94.96 Cryptococcus Infection 5 55.12 Sprains And Strains 6 5.00 Candida Infection 5 5.00 Urological Neuroanatomy 2 5.00 Granuloma 2 5.00 Targeted Disruption 2 5.00 Hypoxia 1 5.00 Communicable Diseases 1 5.00

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This study establishes a key role for SMS in the regulation of the killing activity of neutrophils against C. neoformans through a DAG-PKD dependent mechanism, and provides, for the first time, new insights into the protective role of host sphingolipids against a fungal infection.

SMS Positive_regulation (role) of Regulation (regulation) of DAG-PKD in neutrophils associated with fungal infection

1) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3011003 Disease Relevance 0.37 Pain Relevance 0.04

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