INT352754

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkd1) nucleus (Prkd1) intracellular (Prkd1)
kinase activity (Prkd1) cytoplasm (Prkd1)
Anatomy Link Frequency
neutrophils 2
Sms (Mus musculus)
Prkd1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 11 89.80 High High
ketamine 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Cholecystokinin 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 33 98.76 Very High Very High Very High
Fungal Infection 19 94.96 High High
Cryptococcus Infection 5 55.12 Quite High
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Candida Infection 5 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Granuloma 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low
Communicable Diseases 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study establishes a key role for SMS in the regulation of the killing activity of neutrophils against C. neoformans through a DAG-PKD dependent mechanism, and provides, for the first time, new insights into the protective role of host sphingolipids against a fungal infection.



SMS Positive_regulation (role) of Regulation (regulation) of DAG-PKD in neutrophils associated with fungal infection
1) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3011003 Disease Relevance 0.37 Pain Relevance 0.04

General Comments

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