INT352765

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (DAG1, Prkd1) nucleus (DAG1, Prkd1) plasma membrane (DAG1, Prkd1)
nucleoplasm (DAG1) intracellular (Prkd1) extracellular space (DAG1)
DAG1 (Homo sapiens)
Prkd1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 22 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Cholecystokinin 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fungal Infection 38 90.36 High High
Infection 66 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Candida Infection 10 5.00 Very Low Very Low Very Low
Cryptococcus Infection 10 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Granuloma 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Communicable Diseases 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since DAG produced by SMS1 or SMS2 regulates the localization of PKD at the Golgi [30], and SMS activity significantly increases in differentiated versus undifferentiated cells (Figure 1B), it was next examined by mass spectrometry whether DAG levels, as a result of SMS activity, would change in differentiated compared to undifferentiated cells.
DAG Spec (examined) Regulation (regulates) of Localization (localization) of PKD
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.09 Pain Relevance 0
It has been shown that diacylglycerol (DAG) produced by SMS1 or SMS2 regulates the localization of PKD at the Golgi [30], and that the PKD at the Golgi, in turn, regulates vesicular trafficking and secretion.
DAG Regulation (regulates) of Localization (localization) of PKD
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0 Pain Relevance 0

General Comments

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