INT35282

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.81
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm4) plasma membrane (Chrm4) signal transducer activity (Chrm4)
Anatomy Link Frequency
brain 1
N1E-115 1
Chrm4 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 3 96.60 Very High Very High Very High
fluoxetine 2 95.20 Very High Very High Very High
Pyramidal cell 56 86.80 High High
antidepressant 4 80.20 Quite High
Eae 1 76.72 Quite High
Hippocampus 20 61.52 Quite High
interneuron 4 60.16 Quite High
Pain 1 53.60 Quite High
tetrodotoxin 1 53.28 Quite High
GABAergic 24 50.00 Quite Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 99.20 Very High Very High Very High
Sprains And Strains 46 97.28 Very High Very High Very High
Depression 3 96.60 Very High Very High Very High
Intellectual Impairment 1 84.08 Quite High
Cognitive Disorder 12 83.40 Quite High
Reprotox - General 2 1 81.48 Quite High
Schizophrenia 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lack of small-molecule ligands that can block or activate specific mAChR subtypes with high selectivity has remained a major obstacle in defining the roles of the individual receptor subtypes and in the development of novel muscarinic drugs.
Positive_regulation (activate) of mAChR
1) Confidence 0.45 Published 2007 Journal Nat Rev Drug Discov Section Abstract Doc Link 17762886 Disease Relevance 0.08 Pain Relevance 0.05
Muscarinic acetylcholine receptor (mAChR) activation in cortical and hippocampal networks acute brain slices induces synchronized activity and network oscillations.
Positive_regulation (activation) of mAChR in brain
2) Confidence 0.01 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.26 Pain Relevance 0.10
Chronic membrane depolarization results in an increase in muscarinic acetylcholine receptor (mAChR) number in N1E-115 neuroblastoma cells.
Positive_regulation (increase) of mAChR in N1E-115 associated with neuroblastoma
3) Confidence 0.00 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 3131483 Disease Relevance 0.10 Pain Relevance 0.05
Here we report that sildenafil increases muscarinic acetylcholine receptor (mAChR) signaling in human neuroblastoma cells.
Positive_regulation (increases) of mAChR associated with neuroblastoma
4) Confidence 0.00 Published 2008 Journal J Neural Transm Section Abstract Doc Link 17823768 Disease Relevance 0.36 Pain Relevance 0.43

General Comments

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