INT352832

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.51
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Miox) cytoplasm (Miox)
Anatomy Link Frequency
oocytes 1
male germ cells 1
Miox (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 54.88 Quite High
adenocard 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 8 99.52 Very High Very High Very High
Reprotox - General 3 8 99.30 Very High Very High Very High
Repression 8 91.64 High High
Germ Cell And Embryonal Neoplasms 4 76.16 Quite High
Testicular Cancer 28 69.92 Quite High
Seminoma 4 45.92 Quite Low
Disorder Of Lipid Metabolism 4 26.72 Quite Low
Male Infertility 4 22.16 Low Low
Neurological Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic studies disrupting miRNA functions in mammals by targeting Dicer, Drosha, DGCR8, or individual miRNAs have revealed specific and global roles of miRNAs a variety of developmental processes and pathologic states.
Regulation (targeting) of miRNAs
1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0.31 Pain Relevance 0
Thus we reject the hypotheses that a) the selection of the more abundant strand (5p vs. 3p) may shift and b) the stability of all miRNAs are coordinately regulated over pubertal testicular development.


Regulation (regulated) of miRNAs
2) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
It is intriguing that newborn ovaries, predominantly composed of meiotic oocytes, show a similar enrichment for expression of miRNAs from chromosomes 2 and X, potentially indicating some common regulation of meiotic miRNAs in both sexes [40].
Regulation (regulation) of miRNAs in oocytes
3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0 Pain Relevance 0
We believe that profiling miRNA changes during normal testicular development will aid in the interpretation of significant changes in miRNAs occurring in pathologic states (i.e., infertility and cancer) and may suggest novel regulation of miRNAs in male germ cells.


Regulation (regulation) of miRNAs in male germ cells associated with reprotox - general 3 and cancer
4) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012074 Disease Relevance 0.20 Pain Relevance 0.05

General Comments

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