INT352860

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (POLR2B, IKBKAP) nucleolus (POLR2B, IKBKAP) nucleus (POLR2B, IKBKAP)
nucleoplasm (POLR2B) protein complex assembly (IKBKAP) cytoplasm (IKBKAP)
POLR2B (Homo sapiens)
IKBKAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Dysautonomia 75 99.84 Very High Very High Very High
Toxicity 5 26.64 Quite Low
Cognitive Disorder 7 15.28 Low Low
Attention Deficit Hyperactivity Disorder 2 10.92 Low Low
Dementia 4 6.56 Low Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Spinal Muscular Atrophy 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This enhancement of RNA polymerase II activity results in a meaningful increase in levels of mRNAs from genes that are usually under expressed, such as IKAP in FD-derived cells.
Positive_regulation (enhancement) of polymerase II Positive_regulation (results) of Positive_regulation (increase) of IKAP associated with familial dysautonomia
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.74 Pain Relevance 0

General Comments

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