INT352867

Context Info Confidence 0.20 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.13 Pain Relevance 0

small molecule metabolic process (CYP7B1) cell death (CYP7B1) endoplasmic reticulum (CYP7B1)

CYP7B1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Familial Dysautonomia 75 64.00 Toxicity 5 9.16 Cognitive Disorder 7 5.00 Dementia 4 5.00 Congenital Anomalies 2 5.00 Attention Deficit Hyperactivity Disorder 2 5.00 Disease 2 5.00 Neuropathic Pain 2 5.00 Spinal Muscular Atrophy 1 5.00 Adhesions 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We confirmed the effect of PS on six significantly up-regulated genes (YWHAH, TM4SF1, MYC, DCTPP1, BLM and BRIP1) and four significantly down-regulated genes (RCAN2, ROBO2, CYP7B1, and ITGB8) using QPCR (Figure 4).

Regulation (effect) of CYP7B1

1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012102 Disease Relevance 0.13 Pain Relevance 0

General Comments

This test has worked.